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| 血清羧化不全骨钙素对绝经后女性骨质疏松症诊疗意义的探讨 |
| Study on the significance of serum undercarboxylated osteocalcin in the diagnosis and treatment of osteoporosis in postmenopausal women |
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| DOI：10.3969/j.issn.1006.7108.2017.12.010 |
| 中文关键词: 羧化不全骨钙素 骨质疏松症 绝经后女性 骨密度 |
| 英文关键词:Undercarboxylated osteocalcin Osteoporosis Postmenopausal women Bone mineral density |
| 基金项目:中国博士后科学基金面上项目(2012M511301) |
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| 中文摘要: |
| 目的 检测绝经后女性血清羧化不全骨钙素（ucOC）的水平，并探讨其影响因素及其对绝经后女性骨质疏松症诊疗的意义。方法 选择南京医科大学附属南京医院2015年07月至2016 年12月在骨科门诊就诊的绝经后女性患者108例，依据骨密度检查将这些患者分为骨质疏松组与非骨质疏松组；记录其年龄、身高、体重、体重指数(BMI)、绝经年龄、骨密度（BMD）等相关资料；抽取外周血测定碱性磷酸酶(ALP)、血钙、血磷、羧化不全骨钙素（ucOC）的水平，并对上述资料进行相关的统计学分析。结果 ①绝经后女性骨质疏松组患者的血清ucOC水平与非骨质疏松组相比差异有统计学意义（P＜0.05）；血清ucOC水平是骨质疏松症的影响因素（OR=2.806，P＜0.05）。②血清ucOC水平与腰椎骨密度呈负相关（r=–0.395，P＜0.05），但与髋关节骨密度无显著相关性（r=–0.248，P＞0.05）。结论 血清ucOC水平的变化与绝经后女性骨质疏松症的发生关系密切，血清高ucOC水平是绝经后女性骨质疏松症发生的危险因素；推断血清ucOC水平对于绝经后女性骨质疏松症早期的预测和筛查具有参考意义。 |
| 英文摘要: |
| Objective To detect the levels of serum undercarboxylated osteocalcin (ucOC) in postmenopausal women, and to explore its influencing factors and its significance in the diagnosis and treatment of osteoporosis in postmenopausal women. Methods Totally 108 patients attending our hospital’s orthopedics clinic were recruited from July 2015 to December 2016. The experimental and control groups were set up according to bone mineral density (BMD) T-score and history of fracture. Age, height, weight, body mass index (BMI) and BMD were recorded, and peripheral blood samples were taken to test blood alkaline phosphatase (ALP), serum calcium, phosphorus and ucOC. Statistical analyses of these indicators were undertaken. Result ① The level of ucOC in patients with osteoporosis was significant higher than that of the control group (P<0.05). Serum ucOC level was one of the influencing factors for osteoporosis (OR=2.806, P<0.05). ② Serum ucOC level had a significant and negative correlation with lumber BMD (r=-0.395, P<0.05), but there was no significant correlation with hip BMD (r=-0.248, P>0.05). Conclusion In postmenopausal women, the change in serum ucOC levels closely associated with the occurrence of osteoporosis, and high serum ucOC level is a risk factor for osteoporosis. Furthermore, serum ucOC level could be used as a reference for the early prediction and screening of osteoporosis in postmenopausal women. |
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