| Objective To observe the effects of hypothyroidism and hyperthyroidism on bone mineral density and bone metabolism. Methods 37 cases of hypothyroidism were included in the hypothyroidism group, 41 cases of hyperthyroidism were included in the hyperthyroidism group and 40 cases of healthy female patients were included in the control group. The thyroid function index of blood free triiodothyronine (FT3), free thyroid hormone (FT4) and highly sensitive thyroid stimulating hormone (TSH), bone metabolic index of Ca2+, blood P3+, 1,25- (OH)2D3, parathyroid hormone (PTH), alkaline phosphatase (ALP), serum type I collagen carboxy terminal pyridine (ICTP) and serum osteocalcin (BGP), as well as the left femoral neck and anteroposterior lumbar spine 1-4 (L1-4) bone mineral density were measured and compared. Results The levels of serum FT3, FT4, ALP, BGP and ICTP in the hyperthyroid group were higher than those in the control group (P<0.05), but the level of serum TSH in the hyperthyroid group was lower than that in the control group (P<0.05). The serum TSH level in the hypothyroidism group was higher than that in the control group (P<0.05), but the levels of serum FT3, FT4, ALP, BGP and ICTP were significantly lower than those of the control group (P<0.05). Bone mineral density of lumbar spine 1-4 and left femoral neck in the hyperthyroidism and hypothyroidism groups were significantly lower than that of the control group (P<0.05). There were no significant differences in PTH, CT, Ca2 +, P3 +, 1,25- (OH) 2D3 among the three groups (P> 0.05). Conclusion Hyperthyroidism and hypothyroidism can cause loss of bone mass and decreased bone density. It is mainly achieved by influencing bone turnover. Attention should be paid to abnormal bone mineral density and abnormal bone metabolism caused by abnormal thyroid function. |