| Objective To observe and study the changes of P1NP and β-CTX in patients after cervical spinal injury, in order to improve the knowledge of osteoporosis bone turnover markers, and to guide clinical work. Methods In our hospital, 69 patients with cervical spinal cord injury were treated from October 2012 to December 2014. Venous blood of all the patients were collected after admission and 2, 4, 8, and 12 weeks after the admission. Serum P1NP and β-CTX levels were detected using luminescence immunoassay, and the results were analyzed and compared. Results P1NP in patients at admission was 31.7± 8.9 ng/mL. It decreased to 22.3± 8.3 ng/mL after 12 weeks, with statistical significance (P<0.05). β-CTX in patients at the admission was 0.41±0.039 ng/mL. It increased to 0.72 ± 0.045 ng/mL after 12 weeks, with statistical significance (P<0.05). P1NP value was higher 2 weeks after the admission but β -CTX was lower than that at the admission. P1NP was 31.7 ±8.9 ng/mL at admission, and it was 30.3± 8.1 ng/mL at 4 weeks after admission, with no significant difference (P>0.05). β-CTX in patients at the admission was 0.41± 0.039 ng/mL, and it was 0.40± 0.052 ng/mL 4 weeks after the admission, with no significant difference (P>0.05). P1NP decreased in 2 weeks, and it was more obvious in patients with smaller BMI. β-CTX increased gradually in 2 weeks, and it was more obvious in patients with smaller BMI. The difference was statistically significant (P<0.05). Conclusion Detection of P1NP and β-CTX after cervical spinal cord injury can reflect accurately the bone metabolism and can prevent osteoporosis in the patients. |