| Glucocorticoids (GC) is one of the most commonly used drugs. Because of its good anti-inflammatory, anti-rheumatism, anti-shock and immunosuppression effects, it is widely used in the treatment of rheumatic diseases, respiratory diseases and other diseases. GC also plays an important role in bone remodeling. However, long-term application of GC can lead to many complications, among which includes bone loss, especially glucocorticoid-induced osteoporosis (GIOP), as the most serious complication. Apoptosis is very important in the maintenance of healthy and normal growth of tissue, but abnormal apoptosis may cause damage to the body. Based on morphological characteristics and molecular changes of apoptosis, there are many methods to detect apoptosis. In recent years, studies have found that osteoblasts are the main target of GC. GC caused bone loss mainly by inhibiting bone formation, and the apoptosis of osteoblasts might be the main cause of GC inhibition of bone formation. This article reviews the role and mechanism of apoptosis in GIOP in order to help to improve the clinical knowledge of GIOP. |