| Objective To investigate changes of bone turnover markers in patients with type 2 diabetes mellitus complicated with microalbuminuria and retinopathy. Methods A total of 301 adult patients with type 2 diabetes were selected. Among those, patients combined with microalbuminuria and (or) retinopathy were divided in the experimental group, and patients without microalbuminuria and retinopathy were divided in the control group. The differences of type I procollagen N-terminal peptide (PINP), beta isomer C-end peptide (β-CTX), and markers of bone turnover between the two groups were compared and analyzed. Results Serum PINP was not statistically significant between two groups (P>0.05). β-CTX was significantly higher in experimental group than that in the control group (P=0.001). Correlation analysis showed that β-CTX was negatively correlated with BUN (r=-0.431, P=0.013), Cr (r=-0.602, P=0.013), UA (r=-0.538, P=0.012), and 25 (OH) D3 (R =-0.703, P=0.036), but was positively correlated with HbA1c (r=0.235, P=0.030) and PTH (r=0.652, P=0.000). Conclusion In type 2 diabetes mellitus patients with microalbuminuria and retinopathy, β-CTX increased significantly, suggesting that β-CTX might be a specific marker for monitoring bone metabolism in type 2 diabetes mellitus patients with microangiopathy. |