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| 复方补肾活血颗粒对肾虚血瘀证绝经后非老年骨质疏松症患者视觉模拟评分和骨密度影响的临床观察 |
| Clinical observation on the effect of compound kidney-invigorating granule on visual analog scale and bone mineral density in postmenopausal non-senile osteoporosis patients with kidney deficiency and blood stasis syndrome |
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| DOI：10.3969/j.issn.1006.7108.2018.01.022 |
| 中文关键词: 绝经后非老年骨质疏松症 肾虚血瘀证 复方补肾活血颗粒 骨密度 视觉模拟评分 |
| 英文关键词:Postmenopausal osteoporosis Kidney deficiency blood stasis syndrome Compound kidney-invigorating granule Visual analog scale Bone mineral density |
| 基金项目:国家中医药管理局中医药重点学科—中医内分泌学（20091221）；国家自然科学基金立项项目(81573944，81603574，81774286)；国家中医临床研究基地业务建设第二批科研专项（JDZX2015123）；安徽省自然科学基金（1708085QH213） |
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| 中文摘要: |
| 目的 观察复方补肾活血颗粒对绝经后非老年骨质疏松症患者视觉模拟评分（Visual Analog Scale，VAS）和骨密度（Bone Mineral Density，BMD）的影响。方法 研究对象选自 2015年6月-2015年12月在本院诊治的肾虚血瘀证绝经后非老年骨质疏松症患者 60例，将患者按照随机函数随机分为两组（对照组和治疗组），每组30例。两组均给予一般治疗，对照组予仙灵骨葆胶囊治疗，治疗组予复方补肾活血颗粒。两组观察时限均为6个月，治疗前后需按照研究方案定期计算中医证候积分，BMD和VAS等指标。结果 临床观察表明，复方补肾活血颗粒治疗组中医证候有效率为90%，对照组为60%，与对照组相比，疗效明显优于对照组(P<0.01)。治疗组中医证候积分为7.96±3.86分，对照组为10.16±3.85分，两组比较具有统计学差异。治疗后治疗组BMD和VAS分别为2.24±0.55 g/cm2、1.96±1.47分，对照组为2.50±0.41 g/cm2、2.86±1.79分，治疗组改善情况优于对照组。结论 复方补肾活血颗粒能显著改善绝经后非老年骨质疏松症患者中医临床症状、BMD和VAS，未见不良事件的发生，复方补肾活血颗粒治疗绝经后非老年骨质疏松症是安全有效的。 |
| 英文摘要: |
| Objective To observe the effect of compound kidney-invigorating granule on visual analog scale (VAS) and bone mineral density (BMD) in postmenopausal non-senile osteoporosis patients. Methods Sixty postmenopausal non-senile patients with osteoporosis and kidney deficiency and blood stasis diagnosed and treated in our hospital were selected from June 2015 to December 2015. The patients were randomly divided into two groups (control group and treatment group), with 30 cases in each group. Patients in both groups received general treatment. The patients in control group was received Xianlinggubao capsule. The patients in treatment group received compound kidney-invigorating granule. The observation period was six months for both groups. Before and after treatment, the TCM syndrome integrals, BMD, and VAS were calculated regularly according to the research program. Results The clinical observation showed that the efficacy on TCM syndromes in the treatment group (90%) was significantly better than that in the control group (60%, P<0.01). The score of TCM syndromes was 7.96±3.86 in the treatment group and 10.16±3.85 in the control group. There was a statistically difference between the two groups. The BMD and VAS in the treatment group were 2.24±0.55 g/cm2 and 1.96±1.47, respectively, and 2.50±0.41 g/cm2 and 2.86±1.79 in the control group, respectively. The improvement in the treatment group was better than that in the control group. Conclusion Compound kidney-invigorating granule significantly improves the clinical symptoms, BMD, and VAS of postmenopausal non-senile patients with osteoporosis, with no occurrence of adverse events. Compound kidney-invigorating granule is safe and effective in the treatment of postmenopausal non-senile osteoporosis. |
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