| Objective To study the correlation between hepatitis B virus (HBV) infection and osteoporosis (OP). Methods The clinical data of 10000 patients admitted to our hospital from January 2008 to January 2016 were analyzed retrospectively. Among them, 2145 HBV infection patients and 2145 non-HBV patients were classified as study group and control group, respectively. The correlation between HBV infection and osteoporosis were analyzed. Results There were no statistically significant differences in age, sex, comorbidities, and drug use profiles between the study group and the control group (P>0.05). The incidence of osteoporosis in patients infected with HBV and non-infected patients was 0.28 and 0.26 per 100 person-years, respectively. After adjustment of age, sex, comorbidities, drug therapy and other factors, the risk of osteoporosis (95%CI) was 1.15 (1.02—1.27) in HBV infection patients. The risk of osteoporosis in HBV infection decreased with age, for patients younger than 49 years of age, the risk of osteoporosis in patients with HBV infection was significantly higher than those with no HBV infection, with a risk ratio of 1.43 (1.17—1.72). The risk of osteoporosis caused by HBV infection decreased with the occurrence of comorbidities, with a risk ratio of 1.02 (0.90—1.17) in those with comorbidities, and of 1.26 (1.08—1.49) in those with no comorbidities. Conclusion HBV increased the risk of osteoporosis, but the impact was little and HBV has no effect on osteoporotic fractures. |