| Objective To investigate the effect of vitamin K2 on bone mineral density, bone metabolism and cytokine levels in patients with hyperthyroidism osteoporosis. Methods 57 patients with hyperthyroidism osteoporosis treated in our hospital from July 2014 to July 2015 were randomly divided into treatment group (n=29) and control group (n=28). The control group was treated with calcium, and the treatment group was treated with vitamin K2 combined with calcium for 12 months. Bone mineral density (BMD) of hip and lumbar spine, bone metabolic index (BGP, PINP) and cytokines (IL-2, IL-6 and IGF-1) were examined and compared before and after treatment. Results Before treatment, BMD, BGP, PINP, IL-2, IL-6 and IGF-1 of the two groups had no significant differences (P>0.05). After 12 months of treatment, BMD of hip and lumbar spine were significantly higher than those in the control group (P<0.05), and the levels of BGP and PINP in the treatment group were significantly lower than those in the control group (P<0.05). The level of IL-2 in the treatment group was significantly higher than that in the control group (P<0.05) and IL- 6 and IGF-1 levels were significantly lower than those in the control group (P <0.05). Conclusion Vitamin K2 could significantly improve bone mineral density, reduce bone turnover, increase IL-2 expression and decrease IL-6 and IGF-1 levels in patients with secondary osteoporosis of hyperthyroidism, thus has protective effect to osteoporosis. |