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| 老年女性2型糖尿病患者骨密度与握力的相关性研究 |
| Correlation between bone mineral density and grip strength in elder female patients with type 2 diabetes |
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| DOI：10.3969/j.issn.1006.7108.2018.03.011 |
| 中文关键词: 2型糖尿病 握力 骨密度 骨质疏松 炎症因子 |
| 英文关键词:Type 2 diabetes Grip strength Bone mineral density Osteoporosis Inflammatory cytokine |
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| 中文摘要: |
| 目的 探索老年女性2型糖尿病患者骨密度与握力的相关性。方法 选取首都医科大学宣武医院内分泌科住院的≥60岁的女性2型糖尿病患者共112名，计算体重指数（BMI）, 测定糖化血红蛋白（HBA1c），C反应蛋白（CRP），白细胞介素6（IL-6）水平及握力；采用双能X线吸收仪测定四肢骨骼肌肌肉含量（ASM）及骨密度（BMD）。分析骨密度与握力，四肢骨骼肌肌肉含量及炎症因子的相关性。结果 老年女性糖尿病患者骨质疏松组BMI、四肢骨骼肌肌肉含量，握力显著低于非骨质疏松组（P＜0.001）。两组CRP, IL-6 无显著差异。相关分析显示年龄与左、右股骨颈的骨密度显著负相关（分别为r=–0.248, P = 0.008; r=–0.232 , P = 0.014）。四肢骨骼肌含量与腰椎的骨密度显著正相关（r=0.280, P = 0.003）。BMI、握力与双侧股骨颈骨密度及腰椎骨密度均显著正相关（r=0.207~0.372, P＜0.05~ P＜0.001）。多元Logistic回归分析显示，BMI、握力是影响骨质疏松的独立危险因素(分别为OR=1.24，P =0.002; OR=1.14，P =0.005 )。结论 握力而不是肌肉含量是影响老年女性2型糖尿病患者骨质疏松的独立危险因素。 |
| 英文摘要: |
| Objective To explore the correlation between bone mineral density and grip strength in elder female patients with type 2 diabetes. Methods A total of 112 elder female patients aged over 60 years old with type 2 diabetes were included in the study. Body mass index (BMI) was calculated. Levels of glycosylated hemoglobin (HBA1c), serum CRP and IL-6, and grip strength were measured. Appendicular skeletal muscle mass (ASM) and bone mineral density (BMD) were assessed with dual energy X-ray absorptiometry. The relationship between BMD and grip strength, skeletal muscle mass, inflammatory cytokines were evaluated. Results Patients with osteoporosis had lower levels of BMI, appendicular skeletal muscle mass, and grip strength than those without osteoporosis (P<0.001). There was no significant difference in serum levels of CRP and IL-6 between the two groups. Correlation analysis showed that age was negatively correlated to BMD of the femoral head of the left and right hips (r=–0.248, P = 0.008; r=–0.232, P = 0.014, respectively). There was a significant positive correlation between ASM and BMD of the lumber vertebrae (r=0.280, P =0.003). BMI and grip strength were positively correlated to BMD of the femoral head of both sides and the lumber vertebrae (r=0.207-0.372, P <0.05 -P <0.001). Multiple stepwise logistic analysis showed that BMI and grip strength were independent risk factors for osteoporosis (OR=1.24, P =0.002; OR=1.14, P =0.005, respectively). Conclusion Grip strength but not muscle mass is the independent risk factor for osteoporosis in elder female patients with type 2 diabetes. |
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