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| 补肾固本方治疗绝经后骨质疏松的临床研究 |
| Clinical study on the treatment of postmenopausal osteoporosis with tonifying the kidney and strengthening the essence prescription |
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| DOI：10.3969/j.issn.1006.7108.2018.04.018 |
| 中文关键词: 补肾固本方 绝经后骨质疏松 骨密度 疼痛 |
| 英文关键词:Bushen recipe Postmenopausal osteoporosis Bone mineral density Pain |
| 基金项目:甘肃省自然科学基金计划(1506RJZA048) |
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| 中文摘要: |
| 目的 补肾固本方治疗绝经后骨质疏松的临床疗效观察。方法 将150例绝经后骨质疏松患者随机分为治疗组和对照组，各75例。治疗组采用补肾固本方治疗，对照组采用阿伦磷酸钠片治疗。结果 治疗组有效率为94.67%，对照组有效率为81.33%，两组比较差异有统计学意义( P＜0.05) ；两组患者治疗后1 个月及6 个月随访疼痛评分与治疗前相比较,有显著性差异(P＜0.05)，治疗组改善效果显著优于对照组（P＜0.05）；治疗6个月后，腰椎、股骨颈、股骨粗隆的BMD均较前明显升高，差异具有统计学意义(P＜0. 05)，治疗组改善效果显著优于对照组（P＜0.05）；两组患者血清BGP、BALP、CT、MMP-2水平较治疗前相比较,有明显性差异(P＜0.05)，治疗组与对照组相比较能够明显提高BGP、ALP、CT水平，降低MMP-2水平，差异均有统计学意义（P＜0.05）。结论 补肾固本方对治疗绝经后骨质疏松患者治疗效果明显。 |
| 英文摘要: |
| Objective To observe the clinical effect of the tonifying the kidney and strengthening the essence prescription in treating postmenopausal osteoporosis. Methods 150 postmenopausal osteoporosis patients were randomly divided into treatment group and control group, with 75 cases in each group. The treatment group was treated with tonifying the kidney and strengthening the essence prescription, while the control group was treated with Alendronate tablets. Results The effective rate of the treatment group was 94.67%, and of the control group was 81.33%, with significant difference between two groups (P < 0.05). Compared with before treatment, the pain scores of the two groups of patients at 1 and 6 months follow-ups were significantly different (P < 0.05), and the improvement was greater in the treatment group compared with the control group (P< 0.05). After 6 months of treatment, BMD of lumbar spine, femoral neck and trochanter were significantly higher than before treatment, the difference was statistically significant (P< 0.05), and the treatment group had significantly greater improvement than the control group (P< 0.05). Compared with before treatment, serum BGP, BALP, CT and MMP-2 of the two groups of patients changed significantly (P< 0.05). Compared with the control group, the treatment group had significantly greater increase in the levels of ALP and BGP CT, and significantly greater decrease in the level of MMP 2 (P< 0.05). Conclusion The treatment of postmenopausal osteoporosis with tonifying the kidney and strengthening the essence prescription (Bushen recipe) is effective. |
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