|
| 骨细胞及干细胞分泌的外泌体在骨重塑中的作用 |
| The role of bone cells and stem cells secreted exosomes in bone remodeling |
| |
| DOI：10.3969/j.issn.1006.7108.2018.04.023 |
| 中文关键词: 外泌体 骨细胞 干细胞 骨重塑 |
| 英文关键词:Exosome Bone cell Stem cell Bone remodeling |
| 基金项目:2017年国家自然科学基金青年科学基金项目（81603641） |
|
| 摘要点击次数: 1162 |
| 全文下载次数: 565 |
| 中文摘要: |
| 外泌体是由多泡体与细胞膜融合后，以外分泌的形式释放到细胞外的直径为 30 ～100 nm 的细胞外囊泡，目前大量研究发现其广泛参与骨相关疾病及骨重塑过程，具有较好的生物学活性。由于成骨细胞和破骨细胞之间的动态平衡在骨重塑过程中起关键作用,而且干细胞在骨重塑方面已显示了巨大的前景，因此,本文就骨细胞及干细胞分泌的外泌体在骨重塑中的作用进行综述,希望能为骨科相关疾病的防治提供研究思路。 |
| 英文摘要: |
| Exosomes are derived from endosomal membranes after the fusion of multivesicular bodies to the plasma membrane, nano-sized vesicles of about 30-100 nm. A large number of studies have found that exosome is widely involved in bone related diseases and bone remodeling process, and has good biological activity. The dynamic equilibrium between osteoblast and osteoclast plays a key role in bone remodeling. What’s more, stem cells have been shown to have a great promise in terms of bone remodeling. Therefore, this review summarizes the roles of bone cells and stem cells secreted exosomes in bone remodeling. We hope to provide research ideas for the prevention and treatment of orthopedic related diseases. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |