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| Runx2基因参与骨代谢相关通路的研究进展 |
| Advance in the research of Runx2 gene in bone metabolism-related pathway |
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| DOI：10.3969/j.issn.1006.7108.2018.04.028 |
| 中文关键词: Runx2基因，骨代谢，信号通路 |
| 英文关键词:Runx2 gene Bone metabolism Signaling pathway |
| 基金项目:广东省科技厅资助项目（20160226）；广东省中医药局科研课题（E1-KFJ110151K49）；广东省医学科学技术研究基金项目（E1-6206-17-110-005） |
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| 中文摘要: |
| 随着老龄化时代的到来，骨质疏松症成为人们研究的热点，而Runx2基因作为一种成骨分化特异性转录因子，参与多种信号通路调控成骨分化的过程。本文仅就Runx2基因参与转化生长因子-β(transforming growth factor-β，TGF-β)、骨形态发生蛋白(bone morphogenetic proteins, BMPs)通路、Notch信号通路及Wnt信号通路的研究进展进行综述。 |
| 英文摘要: |
| With the coming of aging era, osteoporosis has become a hot topic. Runx2 gene, as a specific transcription factor of bone differentiation, is involved in a variety of signaling pathways regulating bone differentiation. This paper reviews the involvement of Runx2 gene in transforming growth factor beta (TGF-β) / bone morphogenetic protein (BMPs) signaling pathway, Notch signaling pathway, and Wnt signaling pathway. |
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