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| 辣木发酵物对大鼠生长、骨骼代谢和骨密度的影响 |
| The effect of fermented moringa on growth, bone metabolism, and bone mineral density in rats |
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| DOI：10.3969/j.issn.1006.7108.2018.05.003 |
| 中文关键词: 辣木发酵物 体重 骨骼生长 骨密度 大鼠 |
| 英文关键词:Fermented Moringa Body weight Bone growth BMD Rat |
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| 中文摘要: |
| 目的 研究辣木发酵物对大鼠生长发育、骨骼代谢和骨密度的影响。方法 选用24只体重（74.38±0.63）g、生长状况良好的清洁级雄性SD大鼠，随机分为实验组和对照组，每组3个重复，每个重复4只。对照组饲喂基础日粮，实验组在基础日粮中添加0.5%辣木发酵物，试验期10周。测量大鼠体重、采食量、股骨湿重、干重和股骨长，血清中钙、磷含量和碱性磷酸酶活性以及腰椎骨骨密度（BMD）。结果 试验组和对照组采食量无明显差异（P>0.05），实验组大鼠体重较对照组有显著增加（P<0.01）；与对照组相比，实验组大鼠的股骨湿重显著增加（P<0.05）,股骨长与腰椎骨密度有极其显著的提高（P<0.01），股骨干重有增加的趋势（P=0.0538）；实验组血清钙含量显著低于对照组（P<0.01），血清磷含量显著高于对照组（P<0.05），两组碱性磷酸酶活性无显著差异（P>0.05）。结论 日粮中添加辣木发酵物能够促进大鼠生长发育，促进大鼠骨骼钙的沉积和骨骼生长，增强骨骼强度。 |
| 英文摘要: |
| Objective To study the effect of the dietary fermented moringa on growth, skeletal metabolism, and bone mineral density (BMD) in growing rats. Methods In the experiment, 24 male SD rats with weight of 74.38±0.63g and good growth status were selected. The rats were randomly allocated to the control group and the experimental group, with 3 repeats in each group and 4 rats in each repeat. The rats in the control group were fed with basic diet, while rats in the experimental group were fed with basic diet supplemented with 5% fermented moringa. All the rats were fed for 10 weeks. The body weight, food intake, the wet and dry weight and length of the femurs were measured. The serum calcium (Ca), phosphorus (P), the activity of alkaline phosphatase, and BMD of lumbar (L2-L5) were measured. Results The food intake had no significant difference between rats in the experimental group and in the control group. Rats in the experimental group had obvious weight gain than those in the control group (P<0.01). Compare with the control group, the wet weight of the femurs in the experimental group increased significant (P<0.05), the length of femurs and the lumbar BMD improved significantly (P<0.01), and the dry weight of femurs had a trend of increase (P=0.05388). Serum Ca content in the experimental group was lower than that in the control group (P<0.01), while P content increased significantly (P<0.05). Alkaline phosphatase activity had no remarkable difference (P >0.05). Conclusion Dietary supplemented with 5% fermented moringa notably promotes weight gain, Ca deposition of bones, and BMD in rats. |
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