中国骨质疏松杂志

乌鲁木齐市229例中老年寻常型银屑病患者骨代谢测定结果分析

Analysis of bone metabolism in 229 middle-aged and elderly patients with psoriasis vulgaris in Urumqi

DOI：10.3969/j.issn.1006.7108.2018.05.014

英文关键词:Psoriasis Psoriasis vulgaris Bone metabolism Osteoporosis

基金项目:

作者	单位
窦清惠1 张新菊2* 孙燕2 邸新颖1 杨静1	1.新疆生产建设兵团医院皮肤科，新疆乌鲁木齐830002 2.新疆生产建设兵团医院内分泌科，新疆乌鲁木齐830002

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中文摘要:

目的探讨寻常型银屑病患者骨代谢结果的差异及影响因素。方法将229例已明确诊断的寻常型银屑病患者作为研究组，同时根据年龄、性别不同选择同期在我院体检中心进行体检的非银屑病健康体检者229例作为对照组。结果男性血清Ca、P银屑病组低于非银屑病组，Mg、ALP、TG、LDL-C男性、女性银屑病组均高于非银屑病组；银屑病组血清25-OH-D3高于非银屑病组；腰椎骨密度男性、女性非银屑病组均略高于银屑病组，男性银屑病组L1、L2及腰椎骨密度均值低于女性银屑病组，腰椎均值具有统计学差异；银屑病组右侧股骨颈及ward’s三角区骨密度略高于左侧；银屑病组患者按不同病程统计银屑病患者出现骨量减低及骨质疏松症大多发生于病程10~15年及5~10年组(分别占28.319%和27.876%)，其次是15~20年组(占22.566%)；分组统计男性组骨密度正常比例明显高于女性组(女性组占8.850%，男性组38.496%)；同组内比较：男性发生骨量减低及骨质疏松症或骨折的比例占44.585%，而女性组占72.222%，明显高于男性组；女性组15～20年组及大于20年组出现骨折，共2例骨折（占2.778%），男性大于20年组出现1例骨折（占0.637%）。结论银屑病患者组骨代谢水平明显低于正常对照组，且在银屑病发病的早期即应该开始骨质疏松的预防教育。

英文摘要:

Objective To investigate the difference of bone metabolism and its influential factors in patients with psoriasis vulgaris. Methods A total of 229 patients with psoriasis vulgaris were identified as the study group. At the same time, according to age and sex, 229 cases of non-psoriatic healthy people who were conducted physical examination in physical examination center of our hospital were as the control group. Results In males, the serum levels of Ca and P in the psoriasis vulgaris group were lower than those in the non-psoriasis vulgaris group. The levels of Mg, ALP, TG, and LDL-C in male and female psoriasis groups were higher than those of non-psoriasis vulgaris group. The serum 25-OH-D3 in psoriatic group was higher than that in non-psoriasis vulgaris group. BMD of the lumbar spine in male and female and non-psoriasis vulgaris group was slightly higher than that in psoriatic group. BMD of L1, L2, and the lumbar spine in male psoriasis group was lower than that in female psoriasis group, and the mean of lumbar spine was statistically significant. BMD of the right femoral neck and Ward triangle in psoriasis group was slightly higher than that of the left side. According to the psoriasis disease course, osteopenia and osteoporosis mostly occurred in 10-15 years and 5-10 years (28.319% and 27.876%, respectively), followed in 15-20 years group (22.566%). The normal proportion of BMD in male group was higher than that in female group (8.850% in female group and 38.496% in male group). In the same group, the proportion of osteopenia and osteoporosis or fracture in males accounted for 44.585%, and in female group accounted for 72.222%, which was significantly higher than in male group. In the female group, there were 2 cases of fractures (2.778%) in 15-20 years group and over 20 years group. In male psoriasis vulgaris over 20 years group, 1 case of bone fracture occurred (0.637%). Conclusion Bone metabolism level in patients with psoriasis vulgaris is significantly lower than that in normal controls. Education of osteoporosis prevention should begin in the early onset of psoriasis.

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