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| 基于Wnt／β-catenin信号通路的中医药干预骨关节炎的研究进展 |
| Research progress of traditional Chinese medicine in the intervention of osteoarthritis based on Wnt/β-catenin signaling pathway |
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| DOI：10.3969/j.issn.1006.7108.2018.05.019 |
| 中文关键词: 中医药，Wnt/β-catenin信号通路的，骨关节炎 |
| 英文关键词:Chinese traditional medicine Wnt/β-catenin Osteoarthritis |
| 基金项目:国家自然科学基金（No．81503477）， 辽宁省教育厅项目（L2015345） |
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| 中文摘要: |
| 骨关节炎是老年人最常见的骨病之一，该病的发病机制尚不明确，除手术外无有效治疗手段。目前Wnt/β-catenin信号通路与骨关节炎已成为研究热点，近年来中医药调控Wnt/β-catenin信号通路干预骨关节炎的研究取得较大进展。作者通过查阅CNKI、维普和PUBMED 数据库近10 年的国内外相关文献，总结了中医药调控Wnt/β-catenin信号通路干预骨关节炎的研究进展,分析这些研究中存在的问题，以期进一步阐明中医药如何通过调控Wnt/β-catenin信号通路干预骨关节炎的分子机制，发掘中医药防治骨关节炎的潜在价值。 |
| 英文摘要: |
| Osteoarthritis is one of the most common bone diseases in the elderly. The pathogenesis of the disease remains unclear, and there is no effective treatment except surgery. The study of the relationship between Wnt/β-catenin signaling pathway and osteoarthritis has become a hot topic. In recent years, Chinese medicine has made great progress in the prevention and treatment of osteoarthritis through regulation of this signaling pathway. By citing domestic and international literatures from CNKI, VIP, PUBMED database in 10 years, the author summarizes the research progress of Wnt/β-catenin signaling pathway in the regulation of osteoarthritis with TCM, and explores the problems in these studies, in order to further deepen the mechanism of traditional Chinese medicine in the prevention and treatment of osteoarthritis and to explore the potential value of TCM. |
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