骨质疏松性骨折诊断技术与风险预测工具研究进展
Advances in diagnostic techniques and risk prediction tools for osteoporotic fractures
  
DOI:10.3969/j.issn.1006.7108.2018.05.021
中文关键词:  骨质疏松性骨折  风险评估  诊断技术  预测模型  研究进展
英文关键词:Osteoporotic fracture  Risk assessment  Diagnostic technique  Prediction model  Research progress
基金项目:国家自然科学基金面上项目“基于两种模型的绝境后骨质疏松性骨折早期预警方法机制研究”(No.81373885);北京市中医药科技发展资金项目“补骨生髓配方颗粒治疗原发性骨质疏松症的临床疗效机理研究”(JJ2015-57)
作者单位
章轶立 魏戌2 申浩1 谢雁鸣1* 1.中国中医科学院中医临床基础医学研究所北京 100700 2.中国中医科学院望京医院科研处北京 100102 
摘要点击次数: 861
全文下载次数: 543
中文摘要:
      目的 对骨质疏松性骨折的风险预测工具种类、优缺点进行总结,以期为该病后续临床与科研提供前期工作基础与参考。方法 从骨质疏松性骨折常见诊断技术和风险评估工具两个角度,综述近五年骨质疏松性骨折的临床诊断技术和国内外常用风险评估工具。结果 诊断技术方面,目前主要有双能X线吸收测定技术、定量超声技术、定量CT技术以及核磁共振技术,大多具有准确、直观等优点,但也有成本高、电离辐射等缺陷;预测工具方面,主要包括骨折风险预测简易工具、国际骨质疏松基金会评估工具、Garvan nomogram评估工具、Q Fracture?算法、亚洲人骨质疏松自我筛选工具、北京友谊医院骨质疏松自我评估工具,其最大优势在于运用简便,但存在灵敏性、特异性、外推性弱等缺陷。此外,考虑了具有中医理论基础的特色症状体征或中医证候要素的风险评估模型,也可为骨质疏松性骨折的早期预防提供必要参考。结论 骨质疏松性骨折的诊断技术与风险评估工具日趋增多,但适应我国骨质疏松性骨折高危人群特征的,兼具准确性、实用性的工具并不多见,宜加紧构建适用于我国人群特征的风险预测工具。
英文摘要:
      Objective To summarize the types, advantages, and disadvantages of risk prediction tools for osteoporotic fractures, so as to provide the basis and reference for the follow-up clinical research and clinical research. Methods From the perspective of common diagnostic techniques and risk assessment tools for osteoporotic fractures, the clinical diagnosis techniques of osteoporotic fractures and the commonly used risk assessment tools nationally and internationally were reviewed. Results In the aspect of diagnosis technology, dual energy X-ray absorption measurement technology, quantitative ultrasound technology, quantitative CT technology, and nuclear magnetic resonance technology were mainly used. They had advantage in accuracy and intuition but had defects in high cost and radiation. In the simple tools for fracture risk prediction, the International Osteoporosis Foundation Assessment Tool, the Garvan nomogram assessment tool, the Q Fracture? algorithm, the Asian osteoporosis self-screening tool, and the Beijing Friendship Hospital Osteoporosis Self-Assessment Tool were used. They had great advantage in easy use, but had defects in sensitivity, specificity, and extrapolation. In addition, traditional Chinese medicine risk assessment model based on the characteristics of symptoms and signs or TCM syndrome could be used in the early prevention of osteoporotic fractures. Conclusion The diagnostic technique and risk assessment tool of osteoporotic fractures are increasing day by day. However, it is not common to adapt to the characteristics of high risk population of osteoporotic fractures in China. Risk prediction tools for Chinese population should be constructed.
查看全文  查看/发表评论  下载PDF阅读器
关闭
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=B75D4BFAB4B08A1B5DFB9D22B80F56FF7EC45F0ECFB6080D8033DA414BBF9AB50F5BDF6BD5AA56E025FCB19845DC684A72B63BFC325933EAD65783206EECCE16C5CE7BD4EB84E815916C70ED06390130EC51E09BA410D03B&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=527A01A248DACB72&jid=CA678592D11E309E8E3FB3B2BFE9BE1A&yid=EA357AD73C8E13BC&aid=2354056DD48CBB455F390166D7B842C7&vid=&iid=94C357A881DFC066&sid=5AE7FA263C8A6D65&eid=34D13857B558254E&fileno=20180521&flag=1&is_more=0"> var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC"; var my_cid="527A01A248DACB72"; var my_jid="CA678592D11E309E8E3FB3B2BFE9BE1A"; var my_yid="EA357AD73C8E13BC"; var my_aid="2354056DD48CBB455F390166D7B842C7";