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| 胰岛素样生长因子1对2型糖尿病合并骨质疏松中骨钙素表达的影响 |
| Effect of insulin-like growth factor 1 on osteocalcin expression in type 2 diabetic patients with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2018.05.023 |
| 中文关键词: 胰岛素样生长因子1 2型糖尿病 骨质疏松 骨钙素 |
| 英文关键词:Insulin-like growth factor 1 Type 2 diabetes mellitus Osteoporosis Osteocalcin |
| 基金项目:国家中医药管理局项目（No:JDZX2015039）；甘肃省中医药管理局项目（No: GZK-2016-49） |
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| 中文摘要: |
| 随着流行病学的调查研究发现，2型糖尿病患者与健康人群相比，其罹患骨折事件的发生率明显增高，所以骨质疏松及骨折等并发症需引起2型糖尿病患者的足够重视。在分子机制层面的研究显示，2型糖尿病合并骨质疏松的发生可能与胰岛素样生长因子1、葡萄糖毒性、硬骨素、骨钙素及氧化应激等多种代谢途径的改变有关。胰岛素样生长因子1是骨形成的调节因子，在调节成骨细胞和破骨细胞介导的骨骼重建过程中起着重要的作用。骨钙素是由成骨细胞产生的一种非胶原蛋白，能够反应成骨细胞的活性，常作为骨形成和骨转换的特异性指标。有研究显示，胰岛素样生长因子1以浓度依赖方式刺激骨钙素的合成增加，本文试就胰岛素样生长因子1对2型糖尿病合并骨质疏松中骨钙素表达的影响做一综述，探讨在2型糖尿病合并骨质疏松患者中胰岛素样生长因子1与骨钙素之间的相关性，以期对2型糖尿病合并骨质疏松患者能够进行早期诊断及治疗，预防骨折事件的发生，提高患者生活质量。 |
| 英文摘要: |
| Epidemiological study shows that the risk of fracture occurrence in patients with type 2 diabetes is higher than that in the healthy population. Therefore, enough attention to osteoporosis and fracture complication should be paid by patients with type 2 diabetes. Studies at the molecular mechanism level shows that the occurrence of type 2 diabetes with osteoporosis may be associated with changes of insulin-like growth factor 1, glucose toxicity, sclerostin, osteocalcin, oxidative stress, and other metabolic pathways. Insulin-like growth factor 1 is a regulator of bone formation. It plays an important role in the regulation of bone remodeling process mediated by osteoblasts and osteoclasts. Osteocalcin is a non-collagen protein produced by osteoblasts. It reflects the activity of osteoblasts, and it is often used as a specific marker of bone formation and bone turnover. Studies have shown that insulin-like growth factor 1 stimulates osteocalcin synthesis in a dose-dependent manner. This paper reviews the effect of insulin-like growth factor 1 on the expression of osteocalcin in type 2 diabetic patients with osteoporosis, the correlation between osteocalcin and insulin like growth factor 1 in type 2 diabetic patients, the early diagnosis and treatment of osteoporosis, prevention of fractures, and the quality of life of the patients. |
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