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| 运动力学刺激对骨质量影响的研究进展 |
| Research progress on the effect of exercise mechanical stimulation on bone mass |
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| DOI：10.3969/j.issn.1006-7108.2018.06.022 |
| 中文关键词: 骨骼 力学刺激 运动 成骨细胞 骨质疏松 |
| 英文关键词:Skeleton Mechanical stimulation Movement Osteoblasts Osteoporosis |
| 基金项目:中央高校基本科研业务费专项资金项目（31920170089）；青少年健康评价与运动干预教育部重点实验室建设项目（40500-541235-14203/004） |
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| 中文摘要: |
| 在力学的刺激下骨骼会发生适应性变化，对骨的重塑和构建产生影响。回顾近年来有关力学刺激促使骨髓间充质干细胞（mesenchymal stem cells，MSC）向成骨细胞（osteoblasts，OB）的分化和细胞形态结构影响的研究，充分揭示力学刺激可以使骨产生适应性改变的作用。大量的研究证实力学刺激能使MSC向OB分化和OB信号通路产生适应性变化。本文主要综述力学刺激可能影响骨量和骨细胞形态适应性变化的细胞分子机制，提出运动产生的力学刺激可能使MSC向OB分化和OB产生适应性变化，为运动健骨防治骨质疏松提供理论依据。 |
| 英文摘要: |
| Under the stimulus of mechanics, skeletal adaptations occur, which affect the remodeling and structure of bone. Research in recent years on the effects of mechanical stimulation in promoting the differentiation of bone marrow stem cells (MSCs) into osteoblasts and its influence on cell morphology and structure was reviewed, and showed that mechanical stimulation can lead to adaptive changes in bone. A large number of studies have confirmed that mechanical stimulation can lead to the differentiation of MSCs into osteoblasts and adaptive changes of the osteoblast signaling pathway. This paper reviewed the molecular mechanisms of the effects of mechanical stimulation on bone mass and bone cell morphology changes, and proposed that the stimuli produced by mechanical movement could lead to the differentiation of MSCs into osteoblasts and the adaptive change of osteoblasts, thus provide a theoretical basis for exercise intervention to prevent and treat osteoporosis. |
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