| In recent years, studies have shown that the occurrence of osteoporosis is often associated with some chronic diseases. This paper analyzed the recent progress on osteoporosis in several chronic diseases such as Alzheimer's disease, cerebral infarction, chronic kidney disease, type 2 diabetes mellitus and atherosclerosis, and explored the relationship between osteoporosis and these diseases. Factors that cause osteoporosis in these diseases include: (1) Inflammatory factors such as TNF-a and IL-6 could suppress the signaling pathways common to these diseases - the Wnt pathway; (2) These common chronic diseases and osteoporosis in the elderly have common risk factors, such as age, sex, smoking, diabetes and high blood pressure, etc; (3) Older elderly due to organ degeneration, often have reduced digestion and reduced absorption ability, resulting in the deficiency of calcium, vitamin D and estrogen that are important for bone health; (4) Older elderly often have a variety of underlying diseases, such as: cerebral infarction, hemiplegia, malignant tumors, which result in reduced outdoor activities, lack of sunlight exposure, reduced exercise, decreased physical fitness and malnutrition. All of these play an important role in the development of osteoporosis. In summary, the incidence of osteoporosis is often associated with a variety of factors, and for elderly people with a variety of other chronic diseases, the risk for osteoporosis is higher. Therefore, we should strengthen bone density monitoring, early diagnosis and early treatment, to avoid the occurrence of fractures. |