| Objective To investigate the changes in bone mineral density (BMD) in patients with latent autoimmune diabetes in adults (LADA), and to explore the related influencing factors. Methods 43 adults with LADA were selected as LADA group, and 40 healthy subjects were selected as control group. Metabolic indexes including fasting plasma glucose (FPG), 2h postprandial blood glucose (2h PBG), glycosylated hemoglobin (HbA1c), serum Ca, serum P, 24h urinary calcium, 24h urinary P, alkaline phosphatase (ALP) and microalbuminuria (MAU), and BMD of lumbar spine (L2-4) and femoral neck were tested and compared between the two groups. Partial correlation analysis was used to evaluate the relationship between L2-4 BMD, femoral neck BMD and metabolic indexes, and linear regression analysis was used to investigate the influencing factors of BMD of L2-4 and femoral neck in patients with LADA. Results There were no significant differences in P, 24h urinary phosphorus and ALP between the two groups (P>0.05). FPG, 2h PBG, HbA1c, 24h urinary calcium and MAU of LADA group were significantly higher than those in the control group (P<0.05), and serum Ca of LADA group were significantly lower than that in the control group (P<0.05). BMD of L2-4 and femoral neck of LADA group were significantly lower than that in the control group (P<0.05). BMD of L2-4 negatively correlated with HbA1c and MAU in patients with LADA (r=-0.351, -0.242; P<0.05), BMD of L2-4 positively correlated with serum Ca in patients with LADA (r=0.396, P<0.05). BMD of femoral neck negatively correlated with HbA1c and MAU in patients with LADA (r=-0.462, -0.118; P<0.05). BMD of femoral neck positively correlated with serum Ca in patients with LADA (r=0.411, P<0.05). Conclusion The BMD of LADA patients was lower than that of healthy people. Sex, serum calcium and MAU are the influencing factors of L2-4 BMD, and age, sex, serum calcium and MAU are the influence factors of femoral neck BMD in patients with LADA. |