| Objective To investigate the effect of total flavones of rhizome drynariae combined with glucosamine sulfate on the symptoms, bone metabolic markers and inflammatory factors in patients with knee osteoarthritis (KOA). Methods From May 2014 to April 2017, 110 patients with KOA were randomly divided into control group and treatment group, with 55 patients in each group. Patients in treatment group received total flavonoids of rhizome drynariae and glucosamine sulfate. Patients in control group received glucosamine sulfate only. The clinical efficacy, the change of Lequesne score and VAS score, serum type I collagen cross-linked C-terminal peptide (CTX-1), serum tartrate-resistant phosphatase allogeneic (TRACP-5b), tumor necrosis factor-alpha (TNF-α), and transforming growth factor-β1 (TGF-β1) between the two groups before and after treatment were compared. The occurrence of adverse reactions in two groups was recorded. Results Before the treatment, there were no significant differences in Lequesne score, VAS score, CTX-1, TRACP-5b, TNF-α, and TGF-β1 between the two groups (P>0.05). After 3 months of the treatment, the Lequesne score and VAS score, the levels of CTX-1, TRACP-5b, TNF-α, and TGF-β1 in both groups were significantly lower than those before the treatment(P<0.05). The effective rate in the treatment group was significantly higher than that in the control group (P<0.05). The occurrence of adverse effect between the two groups was not statistically significant (P>0.05). Conclusion Total flavonoids of rhizome drynariae combined with glucosamine sulfate has a good clinical effect in the treatment of KOA. |