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| 骨代谢标志物在乳腺癌骨质疏松中的评估价值 |
| Evaluation value of bone metabolic markers in breast cancer patients with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2018.07.011 |
| 中文关键词: 骨代谢标志物 乳腺癌骨质疏松患者 骨痛程度 骨转移数目 诊断指标 |
| 英文关键词:Bone metabolic markers Osteoporosis in breast cancer patients Bone pain degree Number of bone metastases Diagnostic index |
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| 中文摘要: |
| 目的 探究骨代谢标志物在乳腺癌骨质疏松中的诊断价值。方法 选取2014年6月至2017年6月在我院住院接受治疗的182例乳腺癌骨质疏松患者为本次研究的研究对象，对本研究对象的骨代谢标志物BALP以及uNTx水平进行检测，统计并对比治疗前后乳腺癌骨质疏松患者骨代谢标志物的变化情况，采用单因素分析方法及多元线性回归分析方法分析影响乳腺癌骨质疏松患者骨代谢标志物水平的因素。结果 乳腺癌骨质疏松患者骨代谢标志物BALP以及uNTx水平明显高于正常水平（P＜0.05），治疗后两者水平均明显低于治疗前（P＜0.05）；单因素分析显示，骨代谢标志物BALP以及uNTx水平与患者骨转移数目呈正相关（P＜0.05），与骨痛程度无明显联系（P>0.05）；多元线性回归分析，骨代谢标记物和骨转移数目是影响患者近期疗效的相关因素。结论 骨代谢标志物水平与骨质疏松有着密切联系，可作为乳腺癌骨质疏松的理想诊断指标，且该指标相对于影像学检查反应敏感性更强。 |
| 英文摘要: |
| Objective To explore the diagnostic value of bone metabolic markers in breast cancer patients with osteoporosis. Methods A total of 182 breast cancer patients with osteoporosis in our hospital from June 2014 to June 2017 were selected. The levels of bone metabolic markers BALP and uNTx were detected. The changes of bone metabolic markers in patients with breast cancer were analyzed and compared before and after the treatment. The influence factors of bone metabolic markers in the patients were analyzed with single factor analysis method and multiple linear regression analysis. Results BALP and uNTx levels were significantly higher in breast cancer patients with osteoporosis than normal (P<0.05), and the levels after the treatment were significantly lower than before the treatment (P<0.05). Single factor analysis showed that the levels of bone metabolism markers BALP and uNTx were positively correlated with the number of bone metastases in the patients (P<0.05), but had no significant correlation with the degree of bone pain (P>0.05). Multivariate linear regression analysis showed that bone metabolism markers and the number of bone metastases were related factors affecting the patients' short-term efficacy. Conclusion Bone metabolism markers are closely related to osteoporosis, which can be used as an ideal diagnostic index for osteoporosis in breast cancer patients, and the index is more sensitive than imaging examination. |
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