| Objective To observe the clinical efficacy of Danqi granule combined with glucosamine sulfate on the treatment of knee osteoarthritis (KOA). Methods One hundred and twenty-eight KOA patients treated in our hospital from July 2014 to June 2017 were randomly divided into control group and treatment group, with 64 patients in each group. Patients in treatment group received Danqi granule combined with glucosamine sulfate. Patients in the control group received sulfuric acid glucosamine only. The clinical efficacy, changes of Lequesne, VAS, WOMAC, and SF-36 scores were compared. The levels of serum interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-ɑ (TNF-α) in the two groups were detected before and after treatment. The occurrence of adverse reactions in the two groups was recorded. Results Before the treatment, there were no significant differences in Lequesne, VAS, WOMAC, and SF-36 score, and the levels of serum IL-1β, TNF-α, and IL-6 between the two groups (P>0.05). After 6-month treatment, Lequesne, VAS, WOMAC, and SF-36 scores, and the levels of serum IL-1β, IL-6, and TNF-α improved significantly in both groups (P<0.05), and it was more significant in the treatment group than in the control group (P<0.05). The efficacy in the treatment group was significantly higher than that in the control group (P<0.05). These was no difference in adverse drug reactions between the two groups (P>0.05). Conclusion Danqi granule combined with glucosamine sulfate significantly alleviates clinical symptoms of KOA. |