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| 骨质疏松症药物治疗的有限元分析研究进展 |
| Research progress of finite element analysis in drug therapy of osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2018.07.027 |
| 中文关键词: 骨质疏松症 药物 治疗 骨微结构 有限元分析 |
| 英文关键词:Osteoporosis Drugs Treatment Bone microstructure Finite element analysis |
| 基金项目:国家自然科学基金项目（81560780 ) |
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| 中文摘要: |
| 骨微结构改善是骨质疏松症药物治疗的目标，可以增加骨强度，降低骨折风险，但目前来看骨微结构和骨强度的评估手段相对不足。利用有限元分析（finite element analysis，FEA)能够很好地模拟各种类型药物治疗骨质疏松症后有限元模型的各种力学状况，分析其生物力学作用机制、验证骨微结构参数变化对骨强度的影响，优化治疗方案，为药物治疗骨质疏松症的骨微结构和生物力学特性研究提供有效的研究方法。本文通过回顾近年来药物治疗骨质疏松症的有限元分析研究，探讨不同种类药物治疗骨微结构参数变化对骨强度的影响，结果发现目前关于药物治疗骨质疏松症的有限元研究有待于对骨微结构有限元模型建立进行标准化和精确化，同时进一步推广有限元研究思路，需要更多大样本的临床随机对照试验来验证疗效，更好的指导药物治疗骨质疏松症的临床运用。 |
| 英文摘要: |
| The improvement of bone microstructure is the goal of drug treatment of osteoporosis， which can increase the bone strength and reduce the risk of fracture. However，the assessment method of bone microstructure and bone strength are relatively inadequate. Finite element analysis (FEA) can simulate the various mechanical conditions after drug treatment of osteoporosis with finite element model，analyze its biomechanical mechanism，verify the changes in bone microstructure parameters of bone strength，and optimize the treatment options. This paper reviews the finite element analysis of drug treatment of osteoporosis in recent years and explores the effect of bone microstructure parameter changes after different drug treatment on bone strength. It is found that the current finite element studies of drug treatment of osteoporosis need standardization and precision in the establishment of bone microstructure FE. More randomized controlled trials are needed to further promote the idea of finite element analysis，and to better guide the clinical application of drug treatment of osteoporosis. |
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