| This review?analyzed and evaluated the application of zebrafish model in bone research. Literatures were selected from Chinese and English database, and then the application status, individual characteristics and research advantages and disadvantages of the two models of the embryo zebrafish and adult zebrafish were reviewed. Literature screening found there were 107 literatures included, and the general classification included osteoporosis direction, bone metabolism direction, bone development direction, bone regeneration and repair direction, drug screening direction, etc. There were 88 references to embryo zebrafish and 26 adult zebrafish literatures. The embryo zebrafish model was mainly used for the development of bone tissue, living staining, establishment of specific transgenic strains and mutants gene screening and high-throughput screening, etc. Adult zebrafish was mainly used in osteoporosis, bone regeneration and repair. The unique structure and physiology of zebrafish provides a new, efficient and flexible animal model for the study of skeletal diseases，and it can provide an important model for Chinese medicine research. |