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| 绝经后骨质疏松症患者血清ICTP、PINP与血脂相关性的研究 |
| Study on the correlation among serum ICTP, PINP, and lipid in postmenopausal patients with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2018.09.014 |
| 中文关键词: 骨质疏松症 ICTP PINP 血脂 |
| 英文关键词:Osteoporosis ICTP PINP Serum lipids |
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| 中文摘要: |
| 目的 探讨绝经后骨质疏松症患者骨代谢指标（ICTP、PINP）与血脂水平的相关性及可能的机制。方法 测定122例绝经后骨质疏松症患者(骨质疏松症组)和122 例绝经后健康正常妇女(正常对照组)的血清ICTP、PINP、TG、TC、LDL-C、HDL-C等指标，并分析其相关性。结果 两组相比较，骨质疏松症组TG、TC、LDL-C高于正常对照组(P＜0.05)，骨质疏松症组HDL-C低于正常对照组(P＜0.05)，骨质疏松症组PINP低于正常对照组(P＜0.05)，骨质疏松症组ICTP高于正常对照组(P＜0.05)；PINP与TG、TC、LDL-C呈负相关，而与HDL-C呈正相关；ICTP与TG、TC、LDL-C呈正相关，而与HDL-C呈负相关。结论 骨质疏松症患者成骨因子PINP水平下降、破骨因子ICTP水平升高与TG、TC、LDL-C升高及HDL-C降低密切相关，高脂血症引起的代谢紊乱与骨质疏松症的发生存在一定的关联性。 |
| 英文摘要: |
| Objective To explore the relationship between bone metabolism index (ICTP, PINP) and blood lipid level and its possible mechanism in postmenopausal patients with osteoporosis. Methods The levels of ICTP, PINP, TG, TC, LDL-C, and HDL-C in 122 postmenopausal patients with osteoporosis (osteoporosis group) and 122 healthy postmenopausal women (normal control group) were determined. The correlation among the factors was analyzed. Results The levels of TG, TC, and LDL-C in osteoporosis group were higher than those in normal control group (P<0.05). The levels of HDL-C in osteoporosis group were lower than those in normal control group (P<0.05). The levels of PINP in osteoporosis group were lower than those in normal control group (P<0.05). The levels of ICTP in osteoporosis group were higher than those in normal control group (P<0.05). PINP was negatively correlated with TG, TC, and LDL-C, but was positively correlated with HDL-C. ICTP was positively correlated with TG, TC, and LDL-C, but was negatively correlated with HDL-C. Conclusion Decreased osteoblastic factor PINP levels and increased osteoclastic factor ICTP levels in osteoporosis patients are closely associated with elevated TG, TC, LDL-C, and decreased HDL-C levels. The metabolic disorders caused by hyperlipidemia have a certain role in the occurrence of osteoporosis. |
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