PKP联合抗骨质疏松药物治疗骨质疏松性椎体压缩骨折的回顾性研究
The treatment of osteoporotic vertebral compression fractures with PKP combined with anti-osteoporosis drugs: A retrospective study
  
DOI:10.3969/j.issn.1006.7108.2018.09.017
中文关键词:  经皮椎体后凸成形术  抗骨质疏松药物  椎体压缩骨折  骨密度
英文关键词:percutaneous kyphoplasty  anti-osteoporosis drugs  vertebral compression fracture  bone mineral density
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相义鹏 付长峰 王元一 刘亚东 张清政 宁聪 徐峰* 吉林大学白求恩第一医院,吉林 长春 130011 
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中文摘要:
      目的 探究经皮椎体后凸成形术(PKP)联合抗骨质疏松药物对于骨质疏松性老年患者椎体压缩性骨折的长期临床疗效。方法 将128例骨质疏松性椎体压缩骨折患者按照坚持服用药物时间长短不同分为A组(小于1年),B组(1-3年),C组(大于3年),比较三组患者治疗前与治疗后6个月、12个月、24个月及36个月的VSA评分、ODI指数、Cobb角变化、椎体丢失高度、骨密度及再发骨折例数。结果 各组患者治疗前各项指标无明显差异,治疗后三组各项指标有不同程度改善。C组的各项指标改善程度优于其他两组,B组的改善程度优于A组。结论 PKP是有效的治疗骨质疏松性椎体压缩性骨折的治疗手段,长期联合抗骨质疏松药物治疗可显著改善全身骨痛情况,增加骨密度,减少再骨折发生率。
英文摘要:
      Objective To explore the long-term clinical efficacy of percutaneous posterior convexoplasty (PKP) combined with anti-osteoporosis drugs in the treatment of vertebral compressibility fractures in elderly patients with osteoporosis. Methods A total of 128 patients with osteoporotic vertebral compression fractures were divided into group A (less than 1 year), group B (1-3 years), and group C (more than 3 years), according to the time length of medication adherence. VSA score, ODI index, Cobb angle change, loss of vertebral body height, bone mineral density, and fracture recurrence were compare among the 3 groups before and after treatment for 6 months, 12 months, 24 months, and 36 months. Results There was no significant difference in the indexes before the treatment. The indexes improved in 3 groups after the treatment. The improvement degree of group C was better than that of the two other groups, and the improvement of group B was better than that of group A. Conclusion PKP is effective in the treatment of osteoporotic vertebral compression fractures. Long-term combination with anti osteoporosis drug treatment can significantly relieve the whole-body bone pain, improve bone mineral density, and reduce the refractures.
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