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| 苏州市0-6岁儿童骨密度调查及其与25羟维生素D关系研究 |
| Analysis of bone mineral density and its relationship with 25-hydroxyvitamin D in children of 0-6 years old in Suzhou |
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| DOI：10.3969/j.issn.1006.7108.2018.09.019 |
| 中文关键词: 骨密度 25羟维生素D 儿童 影响因素 |
| 英文关键词:BMD 25-hydroxyvitamin D children influencing factors |
| 基金项目:苏州市科技局项目（SYSD2017104） |
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| 摘要点击次数: 2006 |
| 全文下载次数: 1567 |
| 中文摘要: |
| 目的 探究苏州市0-6岁儿童骨密度养状况和影响因素及其与25羟维生素D关系，为预防儿童骨密度不足提供科学依据。 方法 选择苏州地区0-6岁儿童481名作为研究对象进行体格测量和相关问卷调查，并采用免疫层析法测定血清25羟维生素D水平和应用定量超声仪检测骨密度。结果（1）定量超声骨密度Z值平均水平为-0.03?0.87，骨密度不足者57名（11.90%）。（2）单因素分析结果显示年龄（?2=10.38，P<0.001）、肉类（t=3.01，P=0.003）摄入和蛋类摄入（t=2.15，P=0.036)、睡眠时间（?2=8.63，P=0.013）、BMI（?2=11.89，P=0.003）、维生素D营养状况（?2=18.37，P<0.001）与儿童骨密度水平有关。（2）二元logistic回归分析显示肥胖（BMI>18）是影响儿童骨密度危险因素（OR=4.730, P=0.003），维生素D充足是其保护因素（OR=0.133, P<0.001）。（3）血清25羟维生素D水平和骨密度值之间存在正性直线相关关系（P<0.001）。结论 1岁内婴儿是防治儿童骨强度不足主要人群，且学龄前儿童骨密度监测工作不可忽视。防治肥胖和合理维生素D补充有利于提高儿童骨密度，促进骨骼健康发展。 |
| 英文摘要: |
| Objective To investigate the status of bone mineral density (BMD) among 0-6 years old children in Suzhou, and its influencing factors and the relationship with 25-hydroxyvitamin D, which could provide scientific evidence for preventing BMD deficiency in children. Methods A total of 481 healthy 0-6 years old children were recruited from Suzhou. Anthropometric indices and the related questionnaire investigation were conducted among all the participants. Serum 25-hydroxyvitamin D level was measured using colloidal gold immunochromatography and BMD was measured using quantitative ultrasound. Results (1) The means and standard deviations of Z-scores were -0.03?0.87. Fifty-seven children (11.9%) had BMD deficiency. (2) Univariate analysis revealed that age (?2=10.38, P<0.001), meat (t=3.01, P=0.003), egg (t=2.15, P=0.036) consumption per week, sleeping time (?2=8.63, P=0.013), BMI (?2=11.89, P=0.003), and vitamin D status (?2=18.37, P<0.001) were associated with BMD. (3) The results of bivariate regression analysis showed that obesity (BMI>18) was the risk factor of BMD (OR=4.730, P=0.003). Meanwhile, the protective factor of BMD was vitamin D status (OR=0.133, P<0.001). (4) There was a positive linear correlation between 25-hydroxyvitamin D and BMD (P<0.001). Conclusion The infants aged 0-1 years old are the most important population of BMD deficiency. It could not to be ignored to monitor BMD deficiency among preschoolers. Prevention and treatment of obesity and appropriate vitamin D supplementation may be beneficial to improve BMD and to promote bone health. |
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