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| 心肺系疾病继发骨质疏松症的病络机制及科学内涵 |
| Pathogenesis and scientific connotation of secondary osteoporosis in cardiopulmonary diseases |
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| DOI：10.3969/j.issn.1006.7108.2018.09.023 |
| 中文关键词: 中医学 骨质疏松症 病络 心血管疾病 慢性阻塞性肺病 |
| 英文关键词:traditional Chinese medicine osteoporosis abnormal collateral cardiovascular disease chronic obstructive pulmonary disease |
| 基金项目:陕西省自然基础研究计划-面上项目（No.2015JM8457）；陕西省教育厅科学研究计划-重点项目（No.16JS026） |
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| 中文摘要: |
| 目前，中医药防治骨质疏松症主要集中在原发性骨质疏松症病机领域，尚缺乏对继发性骨质疏松症病机的联动认识，未能有效建立贯穿于骨质疏松症发生演变的核心理论，并深入揭示其科学内涵。基于骨质疏松症发生的分子生物及临床流行病学研究结果，心肺疾病引起继发性骨质疏松症，与血管生成及偶联，血钙、血铁等血液成分失常密切相关，较为符合中医学络病学说的“病络”机制。心肺系疾病促发骨质疏松症发生，主要体现在“心主血，血液浊化引起络脉功能异常”、“心主脉，脉管络结引起络脉结构改变”、“肺朝百脉，气血失调引起络脉功能改变”等络脉损伤方面，而在疾病发展、病情演变过程中，心肺疾病与骨质疏松症也常通过络脉相互影响。因此，以病络及心肺藏象理论，阐发心肺疾病继发骨质疏松症的病络病机特点及现代科学内涵，综合调治原发疾病及继发骨质疏松，更为符合中老年人多种慢性疾病缠身的现实情况，也与真实世界临床治疗效果研究理念相一致，对于提高本病的临床辨治效果，具有重要的理论指导价值。 |
| 英文摘要: |
| At present, prevention and treatment of osteoporosis with traditional Chinese medicine (TCM) is mainly focused on the field of pathogenesis of primary osteoporosis. There is still a lack of linkage understanding of pathogenesis of secondary osteoporosis. Meanwhile, it also fails to set up the core theory throughout the occurrence and development of osteoporosis to further reveal its scientific connotation. Based on the research results of molecular biology and clinical epidemiology of osteoporosis, heart and lung diseases cause secondary osteoporosis. They have a close relation with angiogenesis and coupling, and disorder of blood calcium and blood iron and other components, which is more consistent with the collateral disease mechanism in TCM theory. Cardiopulmonary diseases promote the development of osteoporosis, mainly by the respect of heart governing blood circulation and blood turbidity causing dysfunction of collaterals, heart governing vessels and vascular network knots causing the change of collaterals structure, lung linking with all vessels and the disorder of Qi and blood causing the change of collaterals function, and other collaterals injuries. In the development and evolution process of the disease, heart and lung diseases and osteoporosis often affect each other through collaterals. Therefore, it is more consistent to the actual situation of chronic diseases in the elderly to explore the pathogenesis and modern scientific connotation of secondary osteoporosis of cardiopulmonary disease with collaterals and cardiopulmonary viscera-state theory, and then to treat primary diseases and secondary osteoporosis comprehensively. It is also consistent with the research concept of clinical efficacy in real world. It has a very important guidance value for the improvement of the clinical efficacy of the disease. |
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