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| 膳食类黄酮对骨健康影响的观察性研究现状 |
| Current status of observational studies on the association between dietary flavonoids and bone health |
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| DOI：10.3969/j.issn.1006.7108.2018.09.026 |
| 中文关键词: 类黄酮 骨质疏松 骨密度 骨质疏松性骨折 观察性研究 |
| 英文关键词:Flavonoids Osteoporosis Bone mineral density Osteoporosis fracture Observational study |
| 基金项目:国家自然科学基金（81460497）；遵义医学院博士启动基金（F-706） |
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| 中文摘要: |
| 随着社会人口老龄化，骨质疏松已成为全人类的重要健康问题，膳食营养因素是预防骨质疏松症的一个重要可控因素。类黄酮是广泛分布在蔬菜、水果等植物性食物中的一类多酚类化学物，根据化学结构可将类黄酮分为六类：黄烷-3-醇、黄酮醇、黄酮、黄烷酮、异黄酮和花青素。类黄酮具有多种生理效应，如抗氧化及抗炎等，很多流行病学研究表明膳食类黄酮对骨健康具有保护作用，但缺乏完整的综述。因此，本文检索Pubmed, Google Scholar, Science Direct，OVID, Web of Science等数据库后，纳入所有关于类黄酮与骨健康的横断面研究和队列研究，排除随机对照试验、干预实验、动物实验、细胞实验、会议总结、综述、书籍、信息不全及无关的文献等，最后纳入10篇。但相同的研究设计较少，且暴露因素差异较大，不同的类黄酮摄入量差异很大，无法将数据合并进行Meta分析，仅对膳食类黄酮与骨质疏松及骨质疏松性骨折关系的观察性研究进行文献综述，为骨质疏松的营养预防提供依据。 |
| 英文摘要: |
| With the aging of the society, osteoporosis has become an important health problem worldwide. Dietary nutrition is an important controllable factor for the prevention of osteoporosis. Flavonoids are, a class of polyphenolic chemicals, widely distributed in plant foods such as fruits and vegetables. According to the chemical structure, flavonoids were divided into six categories: flavan-3-ol, flavonols, flavone, flavanone, isoflavones and anthocyanins. Flavonoids have many physiological functions, such as strong anti-oxidation and anti-inflammatory effects. A number of epidemiological studies have shown that dietary flavonoids have a protective effect on bone health, but there were no complete review. Therefore, we searched databases such as pubmed, google scholar, science direct, OVID, Web of science and so on. Randomized controlled trials, interventional experiments, animal experiments, cell experiments, conference summaries, reviews, books, incomplete information, and irrelevant literature etc. were excluded, and 10 articles were included in this analysis. However, the study design was rarely the same, the exposure factors varied greatly, and the intake of flavonoids also varied greatly. Thus the data could not be combined using meta-analysis. Therefore, this article only reviewed observational studies of the relationship between dietary flavonoids and osteoporosis and fractures, in order to provide a comprehensive evidence for nutritional prevention of osteoporosis. |
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