| Objective To study the characteristics of bone metabolism and the adverse reactions to initial zoledronic acid injection in elderly osteoporosis patients aged over 80 years. Methods 216 osteoporosis patients who attended the Department of Geriatrics or Osteoporosis Department of our hospital from January 2011 to September 2017 were retrospectively analyzed. They were divided into three groups, the elderly group (aged over 80 years, n=96), young elderly group (aged 65 to 80 years, n=80) and postmenopausal non-elderly group (postmenopausal women aged under 65 years, n=40). The differences in blood calcium, blood phosphorus, serum C-terminal telopeptide of type I collagen (CTX), procollagen type 1 N-peptide (P1NP), parathyroid hormone (PTH), 25 hydroxyvitamin D (25OHD) and clinical indexes between groups were measured and compared. 140 patients were treated with zoledronic acid 5mg for the first time, they were divided into 80+ group (aged over 80 years, n=75) and 80- group (aged under 80 years, n=65). The acute phase adverse reaction (APR) of the two groups were observed during the first two weeks after the infusion of zoledronic acid. Results The serum creatinine level in young elderly group was higher than that in the postmenopausal non-elderly group (P=0.01). Compared with postmenopausal non-elderly group, the elderly group had higher blood creatinine (P=0.000), lower 25OHD (P=0.007) and higher PTH (P=0.032). With the increase in age, the level of CTX and P1NP declined (P<0.01), though there were no statistical differences between the groups. The overall incidence of APR in group 80+ was not significantly different from that in group 80-, and the incidence of fever and muscle pain was lower in group 80+, P<0.05. Conclusion The bone metabolism of senile osteoporosis patients aged over 80 years was not all in a relatively low bone turnover state. Common adverse reactions such as fever, muscle and bone pain incidence was lower in elderly patients aged over 80 years after the initial zoledronic acid therapy. |