|
| 血清抗酒石酸酸性磷酸酶-5b和组织蛋白酶K随年龄及绝经变化的分析 |
| Analysis of the change of serum tartrate-resistant acid phosphatase-5b and cathepsin K with age and menopause |
| |
| DOI：10.3969/j.issn.1006.7108.2018.11.002 |
| 中文关键词: TRACP-5b 组织蛋白酶K 骨转换标记 参考区间 西南地区 |
| 英文关键词:TRAP-5b CTSK bone turnover markers reference intervals Southwest region |
| 基金项目:安徽省教育厅自然科学研究重点项目（KJ2016A249）；安徽省教育厅质量工程重点教学研究项目（2016jyxm0333）；安徽省教育厅《高等职业教育创新发展行动计划（2015-2018年）》项目（XM-01-183） |
|
| 摘要点击次数: 2071 |
| 全文下载次数: 1529 |
| 中文摘要: |
| 目的 调查西南地区不同年龄组健康女性抗酒石酸酸性磷酸酶-5b（TRACP-5b）、组织蛋白酶K（CTSK）的总体趋势和分布情况，并确定绝经状态对二者的影响。方法 共研究了2125名女性[包括绝经前（n = 1557）和绝经后（n = 568）妇女，年龄分别为20~79岁]。所有纳入研究的女性均在标准化条件下采集静脉血样，并采用ELISA法测定血清中TRACP-5b和CTSK含量，通过双能X射线吸收测定法测定腰椎（L1-L4）和股骨颈的骨密度（BMD）值。结果 随着年龄的增加，TRACP-5b、CTSK发生适度变化，均逐渐增加，并且在60岁以后TRACP-5b和CTSK水平均保持稳定。与绝经前妇女相比，绝经后妇女的血清TRACP-5b、CTSK、完整PTH均显著增加（P<0.05），而Mg水平均显著降低（P <0.05）。与绝经前相比，不同绝经年限妇女的TRACP-5b、CTSK水平均显著增加（P <0.05）。逐步多元线性回归分析发现，年龄、BMI、FSH、LH和PTH是TRACP-5b的影响因素，CTSK的影响因素包括年龄、BMI、FSH、LH和PTH。结论 建立的TRACP-5b、CTSK参考区间值有助于在很长时期内评估该西南地区妇女骨转换情况。 |
| 英文摘要: |
| Objective To investigate the general trend and distribution of tartrate-resistant acid phosphatase-5b (TRACP-5b) and cathepsin K (CTSK) in randomly selected healthy pre-menopausal women in Southwest China, and to determine the effect of menopausal status on TRACP-5b and CTSK. Methods A total of 2125 women were studied, including 1557 pre- menopausal and 568 post-menopausal women, respectively, and their age was from 20 to 79 years old. Blood samples of all studied women were collected under standardized condition. Serum content of TRACP-5b and CTSK was measured with ELISA method. Bone mineral density (BMD) of the lumbar spine (L1–L4) and the femoral neck was measured using dual energy X-ray absorptiometry. Results With the increase of age, TRACP-5b and CTSK increased moderately and gradually. TRACP-5b and CTSK remained stable after 60 years of age. Compared with those in premenopausal women, serum TRACP-5b, CTSK, and intact PTH increased significantly in postmenopausal women (P<0.05), while Mg level decreased significantly (P<0.05). Compared with those in premenopausal women, TRACP-5b and CTSK levels increased significantly in women with different years after menopause (P<0.05). Stepwise multiple linear regression analysis showed that the influential factors of TRACP-5b included age, BMI, FSH, LH, and PTH, and factors influencing CTSK included age, BMI, FSH, LH, and PTH. Conclusion The results of reference interval values of TRACP-5b and CTSK may help to evaluate the long-term bone turnover rate in women in Southwest China. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|