中国骨质疏松杂志

近10年来我国中老年人群骨质疏松症患病率的荟萃分析

The prevalence of osteoporosis in Chinese middle-aged and elderly population in recent 10 years: A meta-analysis

DOI：10.3969/j.issn.1006.7108.2018.11.004

英文关键词:recent 10 years middle-aged and elderly osteoporosis prevalence meta-analysis

基金项目:国家自然科学基金项目（81774362，81303004）

作者	单位
罗令1 孙晓峰2* 皮丕喆3* 应凯强3	1.中南大学湘雅三医院骨科，湖南长沙 410000 2.湖南中医药大学组织学与胚胎学教研室，湖南长沙 410208 3. 湖南中医药大学图书馆，湖南长沙 410208 4.长沙医学院医学检验系，湖南长沙 410219

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中文摘要:

目的通过荟萃分析，了解近10年来我国中老年人群骨质疏松症（osteoporosis, OP）的患病率情况。方法检索PubMed、Medline、EMBASE 、Cochrane、CNKI、万方、维普数据库，收集2007年1月到2017年12月期间我国中老年人群OP患病率的研究，提取相关数据，选择Stata12.0软件分析结果。结果共纳入17篇研究，≥40岁的样本共36202例，其中OP样本7711例。本研究异质性显著，故采用随机效应模型合并效应量。荟萃分析显示（95%CI）：近10年来，我国中老年人群的OP总体患病率为23%（19%~26%），其中女性27%（23%~31%），男性16%（12%~20%），男女差异显著，与年龄呈正相关。结论近10年来，我国中老年人群OP患病率明显上升，为高发病，形势较严峻，开展相关防治行动意义重大。

英文摘要:

Objective To learn the prevalence of osteoporosis (OP) in Chinese middle-aged and elderly population in recent 10 years with a meta-analysis. Methods The databases of PubMed, Medline, EMBASE, Cochrane, CNKI, Wan fang, and VIP were searched from January 2007 to December 2017. The prevalence of OP in Chinese middle-aged and elderly population was collected. The relevant data were extracted and analyzed using Stata 12.0 software. Results A total of 17 studies were enrolled, including 36,202 over 40-year-old patients. Among those, 7711 were OP samples. The heterogeneity of this study was significant, so the random effect model was used to combine the effects. The meta-analysis showed that in recent 10 years, the overall prevalence of OP in Chinese middle-aged and elderly population was 23% (19%-26%), including 27% (23%-31%) in females and 16% (12%-20%) in males. There was a significant difference of OP prevalence between men and women. OP prevalence was positively correlated with age. Conclusion In recent 10 years, the prevalence of OP in Chinese middle-aged and elderly population has increased significantly. It is a high incidence disease and the situation is severe. Therefore, it is of great significance to carry out relevant prevention and control action.

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