| Objective To explore the relationship between the blood neutrophil/lymphocyte ratio (NLR) and bone mineral density (BMD) in postmenopausal patients with type 2 diabetes mellitus. Methods According to the BMD, a total of 185 postmenopausal patients type 2 diabetes mellitus were classified into normal bone mass group, osteopenia group, and osteoporosis group. The clinical data of all the patients were recorded. The relevant biochemical parameters were detected and BMD was measured. All the parameters were compared among the three groups. At the same time, the relationship between NLR and BMD was analyzed. Results NLR level in the osteoporosis group was significantly higher than that in the normal bone mass group and osteopenia group (P<0.05). When the age, disease course, menopause years, and body mass index (BMI) were adjusted, partial correlation analysis showed that BMD was negatively correlated with NLR and triglyceride (TG) in postmenopausal patients with diabetes mellitus (r= –0.470, P< 0.001; r=–0.218, P=0.003). Multiple factor linear regression analysis showed that age, disease course, menopause years, and NLR were main influential factors of BMD in postmenopausal patients with type 2 diabetes. Conclusion The increase of NLR level in postmenopausal patients with type 2 diabetes is related to BMD, indicating that inflammation plays an important role in the occurrence and development of osteoporosis. |