| Objective To investigate the relationship between bone metabolic markers and degree of retinopathy in postmenopausal women with type 2 diabetes mellitus, and to analyze the related factors. Methods The correlation between the degree of retinopathy and the biochemical markers of bone metabolism in 178 postmenopausal women with type 2 diabetes was retrospectively analyzed, and the possible mechanism was discussed. Results The degree of retinopathy was not significantly correlated with age, BMI, PTH, N-MIDoc, Ca, P, Ca×P, and HbA1C. With the progression of retinopathy, the course of disease, β-CTX, and T-PINP became upward trend, and C peptide, VitD-T, BMD of the right forearm, T score decreased gradually, with significant differences among the groups (P<0.05). Spearman correlation analysis showed that the course of disease was negatively correlated with BMD and T values of the right forearm, C-peptide was positively correlated with ViTD-T, and HbA1C was negatively correlated with PTH, N-MIDoc and T-PINP. Conclusion The biochemical markers of bone metabolism in postmenopausal women with type 2 diabetes have a significant correlation with the degree of retinopathy, indicating that diabetic osteopathy is another form of diabetic microvascular disease. |