| Objective To explore the efficacy of six-ingredient rehmannia pill combined with salmon calcitonin on the pain symptom in postmenopausal osteoporosis. Methods A total of 136 patients with postmenopausal osteoporosis were randomly divided into treatment group (N=68) and control group (N=68). The patients in the control group received salmon calcitonin, and the patients in the treatment group received six-ingredient rehmannia pill combined with salmon calcitonin for 3 months. The levels of tumor necrosis factor-α (TNF-α), type I collagen C-terminal peptide (CTX-I), tartrate-resistant acid phosphatase-5b (TRACP-5b), insulin-like growth factor-1 (IGF-1), and the scores of NRS, VAS, Oswestry dysfunction index (ODI), and JOA (JOA) in the two groups were determined. At the same time the efficacy and adverse drug reaction were record. Results Before the treatment, there were no statistically significant differences in bone metabolic parameters, inflammatory factors, and scores of NRS, VAS, ODI, and JOA between the two groups (P>0.05). After 3 months of treatment, the scores of NRS, VAS, ODI, and JOA in the two groups improved to varying degrees. The above-mentioned scores in the treatment group improved more significantly, and there was a statistically significant difference compared with the control group (P<0.05). After treatment, the levels of serum TRACP-5b, TNF-α, and CTX-I were lower than before treatment (P<0.05), and IGF-1 levels were significantly higher than before treatment (P<0.05). The change was more significant in the treatment group. There was a statistically significant difference between the two groups (P<0.05). The efficacy in the treatment group was significantly higher than that in the control group. The adverse drug reaction was not statistically significant (P>0.05). Conclusion Six-ingredient rehmannia pill combined with salmon calcitonin has significant effect on relieving postmenopausal osteoporotic pain symptom. |