| Objective To explore the mechanism of warming kidney and retention formula in relieving osteoporosis and lipid metabolic abnormality. Methods The ovaries of 60 rats were completely removed to establish postmenopausal osteoporosis model. The rats were then randomly divided into control group (n = 20), estrogen group (n = 20), and the experimental group (n = 20). A small amount of fat was removed from around the ovary only in rats of the false castration group (n=20). After 8 weeks of intervention, the serum levels of type I collagen amino end lengthening peptide (PING), osteoprotegerin (OPG), tartrate acid phosphatase-5b (TRACP5b), and osteocalcin (BGP) were measured using ELISA method. The blood lipid index was measured with an automatic analyzer. Results Compared with the rats in the false castration group, the BMD value of the femur and the proximal femur in the control group decreased significantly (P<0.05), and all the levels of bone metabolism index and lipid metabolism index deteriorated significantly (P<0.05). After gavage treatment, compared with the control group, the BMD value of the femur and the proximal femur in the estragen group and the experimental group increased significantly (P<0.05), and the levels of PING, TRACP5b, and BGP in both groups increased significantly (P<0.05), while the level of OPG reduced significantly (P<0.05). In addition, the levels of lipid metabolism in the estrogen group and the experimental group significantly improved than those in the control group (P<0.05). Conclusion Warming kidney and retention formula effectively improves bone mineral density, regulate bone metabolism and lipid metabolism, and achieve the effect of relieving osteoporosis and regulating blood lipid metabolism by effectively improving bone mineral density of postmenopausal osteoporotic rats. |