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| 补肾通络方联合甲氨蝶呤治疗类风湿关节炎合并骨质疏松的疗效观察 |
| Clinical observation of the efficacy of nourishing kidney and activating meridian recipe combined with methotrexate on the treatment of rheumatoid arthritis with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2018.11.022 |
| 中文关键词: 中医中药 类风湿关节炎 骨质疏松 补肾通络方 |
| 英文关键词:Chinese traditional medicine rheumatoid arthritis osteoporosis nourishing kidney and activating meridian recipe |
| 基金项目:甘肃省第三批五级中医药师承教育工作项目；甘肃省科技厅青年科技基金项目（17JR5RA055） |
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| 中文摘要: |
| 目的 观察补肾通络方联合甲氨蝶呤治疗类风湿关节炎合并骨质疏松的临床疗效。方法 80例类风湿关节炎合并骨质疏松的患者，按照随机数字表分为治疗组和对照组，对照组给予甲氨蝶呤和维D钙咀嚼片，治疗组在上述药物基础上给予补肾通络方，治疗周期均为6个月，观察治疗前后患者的临床症状及体征变化情况，检测患者的骨代谢指标、炎症指标以及骨密度的变化情况。结果 两组患者的总有效率，治疗组为90%，对照组为70%，两组患者治疗前后骨代谢指标、骨密度、临床症状及炎症指标比较，差异显著，具有统计学意义，P<0.05。结论 补肾通络方治疗类风湿关节炎合并骨质疏松患者的临床效果显著，能够明显改善患者的临床症状，很好的调节骨代谢，值得在临床上推广使用。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of nourishing kidney and activating meridian recipe combined with methotrexate on the treatment of rheumatoid arthritis with osteoporosis. Methods Eighty cases of rheumatoid arthritis with osteoporosis were divided into treatment group and control group according to the random number table method. The patients in the control group was given methotrexate and vitamin D calcium chewable tablets, and patients in the treatment group received nourishing kidney and activating meridian recipe in addition of above drugs. The treatment period was 6 months. The changes of clinical symptoms and signs were observed before and after the treatment. Results The total effective rate of the two groups was 90% in the treatment group and 70% in the control group. There were significant differences in the bone metabolic indexes, bone mineral density, clinical symptoms, and inflammatory indexes between the two groups before and after the treatment (P<0.05). Conclusion Nourishing kidney and activating meridian recipe has a significant clinical effect on treating patients with rheumatoid arthritis and osteoporosis. It obviously relieves the clinical symptoms, regulates bone metabolism, and it is worth popularizing in the clinic. |
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