| Objective To investigate the correlation between bone formation index molecular fragment of osteocalcin N terminal (N-MID), bone resorption index β-cross-linked C-telopeptide of type I collagen (β-CTX) and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM). Methods According to the results of dual energy X-ray absorptiometry BMD examination, 233 T2DM cases were divided into normal bone mass group (103 cases), osteopenia group (106 cases) and osteoporosis group (24 cases). General clinical baseline data，such as gender, age, duration of diabetes and blood pressure, were recorded. Biochemical indexes including triglyceride (TG), serum total cholesterol (TC), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS), calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathyroid hormone (PTH), N-MID and β-CTX were detected and compared between the three groups. Results There was statistical difference in age among three groups (P<0.05). There were no significant differences in the percentage of males and females, duration of diabetes, SBP, DBP, TC, LDL-C, HDL-C, TG, FPG, GSP, HBA1C, FINS, C-peptide, CRP, HCY, ACR, Ca, P, ALP and serum 25(OH)D3 among the three groups (P>0.05). There were statistical differences in β-CTX, N-MID and PTH among the three groups (P<0.05). The presence of abnormal bone mass positively correlated with age, β-CTX and N-MID (P<0.05), but was not significantly correlated with serum 25(OH)D3 and PTH (P>0.05). Serum 25(OH)D3 and PTH were negatively correlated (P<0.05), PTH and β-CTX and N-MID were positive correlated (P<0.05), and β-CTX and N-MID were positive correlated (P<0.05)。Conclusion In type 2 diabetes mellitus patients with osteoporosis, the level of bone turnover is relatively high, bone formation has a coupling relationship with bone resorption, osteoclast activity is increased, and bone resorption is dominant. The determination of the concentrations of β-CTX and N-MID can reflect the changes in bone metabolism and evaluate the situation of bone turnover, which provides an important basis for the early diagnosis of osteoporosis. |