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| 仙灵骨葆胶囊治疗绝经后骨质疏松症有效性的系统评价和Meta分析 |
| The effectiveness of Xianling Gubao capsule in the treatment of postmenopausal osteoporosis:a systematic review and meta-analysis |
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| DOI：10.3969/j.issn.1006-7108.2019.01.010 |
| 中文关键词: 中医中药 仙灵骨葆胶囊 绝经后骨质疏松症 系统评价 Meta分析 |
| 英文关键词:Chinese traditional medicine, Xianling Gubao capsule postmenopausal osteoporosis systematic review meta-analysis |
| 基金项目:北京中医药科技发展资金项目(JJ2016-79);中华中医药学会(2017-2019年度)青年人才托举工程项目(CACM-2017-QNRC2-A03) |
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| 中文摘要: |
| 目的 评价仙灵骨葆胶囊治疗绝经后骨质疏松症的有效性和安全性。方法 电子检索中、英文数据库共7个(自建库时间至2017年11月)，按照纳人标准和排除标准筛选文献，依据Cochrane Handbook for Systematic Reviews of Interventions ( veneion 5.35)质量评估，并用RevMan 5. 3软件进行Meta分析。结果 检索到文献共1 779篇，筛选后纳人文献16篇(19项原始研究)，总样本量1 492例。Meta分析得出单用仙灵骨葆胶囊对于提高腰椎骨密度疗效优于常规治疗[MD=0.08,95%CI (0. 03,0. 14) ,P=0. 002]; 仙灵骨葆胶囊加常规干预对于提高临床有效率[OR=3.35,95%CI(1.86,6.05),P<0.0001}、改善疼痛[ MD=–1. 71,95% CI(–2. 39，–1. 03) ,P<0. 000 01]疗效优于常规治疗;在改善腰椎骨密度方面，仙灵骨葆胶囊+单一常规干预疗效明显优于单一常规干预[MD=0.06,95%CI(0.04,0.07) ,P<0.000 01};仙灵骨葆胶囊联合常规干预在提高髋部骨密度疗效上可能优于常规干预[MD=0.08,95%CI(0.03,0. 14) ,P=0.001 ]。结论 仙灵骨葆胶囊在改善腰椎骨密度、提高临床有效率及改善疼痛方面疗效确切;但在改善髋部骨密度方面证据不足，总疗程可能是其重要影响因素;仙灵骨葆胶囊联合单一抗骨质疏松药物具有增效作用，与两种或以上抗骨质疏松药物联用叠加增效作用尚待研究。 |
| 英文摘要: |
| Objective To evaluate the efficacy and safety of Xianling Gubao capsule in the treatment of postmenopausal osteoporosis. Methods Seven electronic databases(from the date of establishment to November 2017)were retrieved. The literatures were screened according to the inclusion criteria and exclusion criteria. All the trials were assessed according to the Cochrane Handbook 5.1 for Systematic Reviews of Intervention and the analyses was performed using RevMan5.3 Software. Results A total of 1 779 articles were retrieved, 16 papers were selected, and 19 original studies were included, with a total sample size of 1 492 cases. Meta-analysis showed that the efficacy of Xianling Gubao capsule alone in improving bone mineral density of the lumbar vertebrae was superior to that of routine treatment(MD 0. 08，95 % CI 0. 03 to 0. 14 ).Xianling Gubao capsule combined with routine intervention was better than routine treatment in terms of improving effective ratio(OR 3. 35，95%CI 1. 86 to 6.05)and pain(MD–1. 71，95 % CI–2. 39 to–1. 03).The curative effect of single routine intervention plus Xianling Gubao capsule was better than that of single routine intervention in bone mineral density of the lumbar vertebrae(MD 0. 06, 95%CI 0. 04 to 0. 07 ).Xianling Gubao capsule combined with routine intervention was superior to routine interventions in improving hip bone mineral density(MD 0. 08，95%CI 0. 03 to 0. 14).Conclusion Xianling Gubao capsule is effective in improving bone mineral density of the lumbar vertebrae, increasing clinical effective rate, and improving pain. However, the advantage in improving hip bone density is not obvious. The total treatment course may be an important influencing factor. Xianling Gubao capsule combined with single anti-osteoporosis drug has synergistic effect, but the synergistic effect is not obvious when combined with two or more anti-osteoporosis drugs.
Key words; Chinese traditional medicine, Xianling Gubao capsule; postmenopausal osteoporosis; systematic review; meta-analysis |
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