| Objective Rheumatoid arthritis(RA)is a common contributor of secondary osteoporosis. The aim of the present study was to explore the risk factors of patients with rheumatoid arthritis occurring osteoporosis(OP)by detecting and analyzing serum rheumatoid factor(RF)，anti-cyclic citrullinated peptide anti-body(anti-CCP )，C reactive protein(CRP )，erythrocyte sedimentation
rate(ESR) and bone metabolism indices levels in patients with RA. Methods 133 RA patients were classified into osteoporosis，osteopenia and normal bone mass groups according to patients’ bone mineral density result determined by dual energy X-ray absorptiometry. RF, anti-CCP, CRP, ESR and bone metabolism indices levels were detected, and differences in the levels of test result and glucocorticoid use situation among groups were compared. Multivariate logistic regression was performed to analyze the association between the presence of OP and serum levels of bone metabolism indices, RF, anti-CCP, CRP and ESR. Results①Serum levels of RF, anti-CCP, CRP and ESR in RA patients were significantly higher than those in healthy individuals;②Levels of CRP, ESR, bone alkaline phosphatase(BALP) and β-crosslaps(β-CTx) were remarkably higher in RA patients with OP or osteopenia than those with normal bone mass，and the glucocorticoid use rate was higher in OP group than normal bone mass group;③Age, disease duration, high disease activity as well as glucocorticoid use were identified to be risk factors independently associated with OP with OR(95 % CI) of 1.116(1. 013-1. 280)，1. 775(1. 191-2. 645)，4. 356(1. 741-10. 898 ) and 9. 448(1. 040-85. 802 )，respectively. Conclusion Serum levels of autoantibodies, inflammatory markers as well as bone metabolism indices elevated to varying degree in patients with RA. Age, disease duration, disease activity and glucocorticoid use can serve as reference indices to evaluate OP risk in RA patients, which is helpful for rheumatologists to monitor disease development and provide reasonable treatments timely. |