中国骨质疏松杂志

2型糖尿病患者血清25-经维生素D水平与骨密度的关系

The relationship between serum 25-hydroxyvitamin D and bone mineral density in patients with type 2 diabetes

DOI：10.3969/j.issn.1006-7108.2019.01.016

英文关键词:type 2 diabetes 25-hydroxyvitamin D bone mineral density

基金项目:蚌埠医学院科研课题(BYKY16167)

作者	单位
黄莹芝1 汤步阳1 郭法平1 朱琦1 叶山东2*	1.蚌埠医学院第三附属医院(皖北煤电集团总医院)内分泌科，安徽宿州234000 2.中国科学技术大学附属第一医院内分泌科，安徽合肥230001

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中文摘要:

目的探讨2型糖尿病患者不同血清25-( OH) D水平与骨密度的关系。方法选择住院的2型糖尿病患者288例，根据25-( OH) D水平对其进行分组：25-( OH) D>30ng/mL为维生素D充足组；20ng/mL <25-( OH ) D≤30 ng/mL为维生素D不足组；l0 ng/mL <25-( OH) D <20 ng/mL为维生素D缺乏组；25-( OH) D <10ng/mL为维生素D严重缺乏组。采用双能X线骨密度仪(DXA)测量受试者腰椎L1-4、股骨颈及全髓的骨密度。分析不同水平25-( OH ) D与骨密度的关系。结果维生素D充足组、维生素D不足组、维生素D缺乏组、维生素D严重缺乏组的患者例数(所占比例)分别为10例(3. 5%) ,74例(25.7%) ,177例(61.5%) ,27例(9.3%)。不同性别组25-( OH ) D水平无明显差异，但是女性患者的腰椎L1-4、股骨颈、全髋的骨密度均较男性低。pearscm相关分析显示25-( OH) D水平与腰椎L1-4、股骨颈、全髓的骨密度均无相关性(分别为r=0.080 P=0.262;r=0. 139 P=0. 051;r=0.068 P=0. 342)。结论 2型糖尿病患者25-( OH) D水平与腰椎L1-4、股骨颈、全髓的骨密度均无明显相关性。

英文摘要:

Objective To investigate the relationships between 25-hydroxyvitamin D and bone mineral density in patients with type 2 diabetes. Methods A total of 288 patients with type 2 diabetes were selected and grouped according to the level of 25-hydroxyvitamin D:sufficiency of vitamin D group(25-(OH) D>30ng/ mL)，insufficient of vitamin D group(20ng/mL< 25-(OH) D≤30ng/mL)，lack of vitamin D group(long/mL < 25-(OH)D < 20ng/mL)，and severe lack of vitamin D group(25-(OH) D < l0ng/mL).Bone mineral density(BMD) of the lumbar L1-4, the femoral neck, and the total hip was measured with dual energy X-ray absorptiometry(DXA).The relationship between 25-(OH) D at different levels and bone mineral density was analyzed. Results The number of cases in sufficiency of vitamin D group, insufficient of vitamin D group, lack of vitamin D group, and severe lack of vitamin D group was 10 cases(3.5%)，74 cases(25.7%)，177 cases(61.5%)，and 27 cases (9. 3 %)，respectively. There was no difference of 25-(OH)D between males and females，but BMD of L1-4，the femoral neck, and the total hip in female patients was lower than that in male patients. Pearson correlation analysis showed that 25-(OH) D level had no obvious correlation with BMD of L1-4，the femoral neck, and the total hip(r=0.080, P=0.262; r=0. 139, P=0.051;r= 0. 068，P=0.342, respectively).Conclusion In type 2 diabetes，the level of 25-(OH)D is not obviously correlated with BMD of L1-4，the femoral neck, and the total hip.

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