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| 降钙素联合骨化三醇胶丸对糖尿病合并骨质疏松症的影响 |
| Effects of calcitonin and calcitonin combined with calcitriol capsule on diabetes mellitus complicated with osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2019.01.019 |
| 中文关键词: 降钙素 骨化三醇 糖尿病 骨质疏松 骨代谢 骨密度 血糖 |
| 英文关键词:calcitonin calcitriol diabetes osteoporosis bone metabolism bone mineral density blood sugar |
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| 中文摘要: |
| 目的 探讨降钙素联合骨化三醇胶丸治疗糖尿病合并骨质疏松症患者对骨代谢、骨密度及血糖的影响。方法 采用配对比较法将我院2011年1月至2015年12月收治的2型糖尿病合并骨质疏松症患者分为接受骨化三醇胶丸治疗的对照组及接受降钙素联合骨化三醇胶丸治疗的观察组，各40例。两组均接受基础降糖治疗，观察两组患者治疗前及治疗1年后骨代谢、血糖、骨密度情况和治疗期间的不良反应。骨代谢指标包括骨钙素(bone gamma-carboxyglutamic-acid-containing proteins,BGP)、β-胶原片段(beta-crosslaps, β-CTX) ,25羟基维生素D[25-hydroxyvitamin D , 25 ( OH ) D ]、人骨碱性磷酸酶( bone alkaline phosphatase , BALP )、甲状旁腺素(parathyroid hormone , PTH )。结果 两组治疗前骨代谢指标、血糖指标及不同部位骨密度对比，差异无统计学意义(P > 0. 05)，观察组治疗1年后BGP、β-CTX、BALP、PTH低于同组治疗前及对照组同期(P < 0.05) , 25(OH)D及不同部位骨密度均高于同组治疗前及对照组同期(P<0. 05)，空腹及餐后2h血糖低于治疗前(P<0.05)，但与对照组相当(P>0.05);观察组总有效率(97. 50%)高于对照组(80. 00%) ( P<0. 05);两组不良反应发生率对比，差异无统计学意义(P>0.05)。结论 降钙素联合骨化三醇对糖尿病合并骨质疏松患者疗效显著，可有效改善骨代谢，治疗骨质疏松。 |
| 英文摘要: |
| Objective To investigate the effects of calcitonin combined with calcitriol capsules on bone metabolism, bone mineral density and blood glucose in patients with diabetes mellitus complicated with osteoporosis，in order to accumulate experience for the promotion and application of this regimen. Methods From January 2011 to December 2015，paired comparison was used to assign patients with type 2 diabetes mellitus and osteoporosis in our hospital to control group receiving calcitriol capsules and to observation group receiving calcitonin combined with calcitriol capsules. There were 40 cases in each group and both groups received basic hypoglycemic therapy. Bone metabolism, blood glucose and bone density were observed before and after 1 year of treatment and the adverse reactions during treatment were observed in both groups. Bone metabolic markers assessed include:Bone Gamma-Carboxyglutamic-Acid-Containing Proteins(BGP)，Beta-Crosslaps(β-CTX)，25-hydroxyvitamin D(25-OHVitD)，human osteogen bone alkaline phosphatase(BLAP) and parathyroid hormone(PTH).Results There were no significant differences in bone metabolism, blood glucose and bone mineral density at different sites before treatment between the two groups. BGP, β-CTX, BLAP and PTH were lower in the observation group after 1 year of treatment compared with before treatment and the control group (P<0.05)，25OHVitD and BMD at different sites were higher than those before treatment and control group at the same time(P<0. 05)，fasting and postprandial 2 h blood glucose were lower than before treatment(P<0.05)，but comparable to the control group(P> 0.05).The total effective rate in the observation group(97. 50%)was higher than that in the control group(80%)(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P> 0.05).Conclusion The combination of salmon calcitonin and calcitriol showed significant effects in diabetic patients with osteoporosis，could effectively improve bone metabolism and treat osteoporosis, and is worthy of promotion in clinical treatment. |
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