中国骨质疏松杂志

大庆市城区部分居民血清维生素D水平评估

Vitamin D status of Daqing urban residents

DOI：10.3969/j.issn.1006-7108.2019.01.021

英文关键词:serum 25-hydroxy vitamin D vitamin D deficiency osteoporosis

基金项目:黑龙江省卫生计生委科研课题(2017-189)

作者	单位
韩雪松1* 李晓丰1 王燕英1 沙宪辉2	1.大庆市人民医院正骨治疗科，黑龙江大庆163000 2.大庆市油田总医院骨外一科，黑龙江大庆163000

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中文摘要:

目的了解大庆市居民血清维生素D水平，为骨质疏松症(osteoporosis , OP)防治提供依据。方法 2014年3月至2016年4月招募大庆市城区居民4874名，其中0~10岁864人，11~20岁298人，21~30岁l55人，31~40岁580人，41~50岁888人，51~60岁927人，61~70岁 750人，70岁以上412人。采集受试者清晨空腹静脉血，应用酶联免疫法测定血清25-羟基维生素D[25 hydroxy vitamin D , 25 ( OH ) D]浓度。以血清25( OH) D<30 nmol/L为维生素D缺乏；血清25(OH)D在30~49. 9 nmol/L之间为维生素D不足；血清25 ( OH ) D≥50 nmol/L为维生素D充足。评估大庆城区居民血清维生素D水平。结果大庆城区部分居民血清25 ( OH) D平均水平为(16. 89±11. 92) nmol/L, 0 -10岁组血清25( OH) D平均水平为(27. 44±14. 90 ) nmol/L;11~20岁组血清25(OH)D平均水平为(13. 86±8. 51) nmol/L; 21~30岁组血清25(OH)D平均水平为(15. 40±13. 41) nmol/L;31~40岁组血清25(OH)D平均水平为(17. 57±12.31) nmol/L;41~50岁组血清25(OH)D平均水平为(13.01±8. 08 ) nmol/L;51~60岁组血清25(OH)D平均水平为(14. 31±9. 20) nmol/L; 61~70岁组血清25(OH)D平均水平为(14. 94±9. 33 ) nmol/L;70岁以上组血清25(OH)D平均水平为(14. 32±9. 58) nmol/L。不同年龄组相比较(完全随机方差分析one way ANOVA检验)，差异有统计意义(F=152.67,P<0.01)。经独立样本t检验，不同性别间差异有统计意义(t=3.05,P=0.002) ,男性高于女性。结论大庆市部分居民普遍存在维生素D缺乏，女性维生素D水平低于男性。

英文摘要:

Objective To assess vitamin D status in Daqing urban residents by two kinds of standards，and to provide a basis for the prevention and treatment of osteoporosis(OP).Methods A total of 4874 people aged from 0 to 75 years in Daqing urban area were enrolled in this cross-sectional study from March 2014 to April 2016. 864(17. 7%)of them aged between 0-10 years，298 (6. 1 %)between 11-20 years，155(3. 2%)between 21-30 years，580(11.9%)between 31-40 years，888(18.2%)between 41-50 years，927(19.0%)between 51-60 years, 750(15.4%)between 61-70 years，and 412(19.0%)over 70 years. Serum 25-(OH) D level was tested using ELISA.①Vitamin D deficiency was defined as serum 25-(OH)D<30 nmol /L;②Vitamin D insufficiency was defined as serum 25-(OH) D 30-49.9 nmol /L; ③Vitamin D sufficiency was defined as serum 25-(OH)D) ≥50 nmol /L. We evaluated the vitamin D status of the residents in Daqing urban area. Results Serum 25-(OH ) D average level of these residents in Daqing city was(16. 89±11. 92)nmol/L, 0-10 years group was(27. 44±14. 90)nmol/L; 11-20 years (13.86±8.51) nmol/L; 21-30 years(15. 40±13. 41)nmol/L; 31-40 years(17. 57±12. 31)nmol/L; 41-50 years(13.01± 8.08) nmol/L; 51-60years(14.31±9.20) nmol/L; 61-70 years(14.94±9. 33)nmol/L; over 70 years(14.33±9.58) nmol/L.We compared different age groups(complete random variance analysis one way ANOVA, F=152. 67，P<0. 001)，and the differences were statistically significant. In the two independent sample t test, the difference between males and females was statistically significant(t = 3. 05，P = 0. 002 )，and men had higher levels than women.

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