| Objective To investigate the relationship between bone turnover and osteoporosis in diabetic patients with different blood glucose control levels, and to provide reference for controlling fracture risk. Methods A total of 494 patients in the Department of Endocrinology of our hospital from January 2017 to September 2018 were enrolled in the study. Glycosylated hemoglobin A1c (HBA1c), 25-hydroxyvitamin D (25-VD), type I collagen amino-lengthening peptide (P1NP), β-crosslaps (β-Cross), and osteocalcin (OC) were measured. According to the level of glycosylated hemoglobin, the diabetic patients were divided into group A (HBA1C < 7.0%), group B (7.0 < HBA1C < 9.0%), and group C (HBA1C < 9.0%). Forty-five non-diabetic people were as the control group during the same period. The results of different groups were analyzed statistically. Results HbA1c was negatively correlated with 25-VD, P1NP, β-Cross, and OC (P<0.05), and the correlation coefficients were – 0.11, – 0.10, – 0.10, and – 0.19, respectively. The four bone metabolic markers in control group were higher than those in diabetic groups (P<0.05). OC level in group A were higher than those in group B and group C (P < 0.05). Conclusion The level of glucose in diabetic patients affects the level of bone turnover markers. OC is more sensitive among bone turnover markers in laboratory detection, which may be more worthy of attention in the diagnosis and treatment monitoring of osteoporosis in diabetic patients. |