围绝经期和绝经后女性骨密度的变化及其相关危险因素分析
Changes in bone mineral density and related risk factors in peri-menopausal and postmenopausal women
  
DOI:10.3969/j.issn.1006-7108.2019.02.010
中文关键词:  骨量减少  骨质疏松  骨密度  绝经后  围绝经期
英文关键词:osteopenia  osteoporosis  bone mineral density  postmenopausal  perimenopause
基金项目:
作者单位
何跃辉* 陈狄 高谦 施平华 汤丽娜 田纪文 徐红伟 北京积水潭医院北京 100096 
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中文摘要:
      目的 观察40岁以上围绝经期和绝经后女性骨密度(bone mineral density,BMD)的变化并分析其相关危险因素。方法 选取2017年8月至2018年3月在我院门诊进行体检的40岁以上女性,详细记录其病史、身高、体重,进行生化和内分泌测试,然后进行双能X射线吸收测定扫描。结果 研究人群的平均年龄为46.65岁,平均体质量指数为26.23 kg/m2。研究中骨量减少的患病率为38%,骨质疏松症的患病率为4%,低骨密度的患病率为42%。随着年龄的增加和绝经状态的增加,低骨密度妇女的比例也随之增加。在内分泌评估中,60%的人群出现维生素D摄入不足的情况,56.67%的人群患有甲状旁腺功能亢进,100%的人群出现甲状腺功能减退,75%的人群伴随着甲状腺功能亢进,同时骨密度较低。在慢性疾病中,发现83.33%的女性患有糖尿病,50%的女性患有高血压,50%的女性具有肝肾功能异常,50%的女性患有关节炎等风湿性疾病,同时骨密度较低。每天接受阳光照射时间少于1 h的女性中,48.65%的人骨密度较低。由于日常体力劳动的减少,BMD正常的女性比例从72.72%下降到46.15%。在多因素Logistic回归分析中,发现血清维生素D缺乏,体力劳动和阳光照射不足与低BMD显著相关。结论 低BMD不是仅限于绝经后妇女的疾病,它在40岁以上的女性中普遍存在。
英文摘要:
      Objective The present study was designed to provide data on women above the age of 40 years with respect to low bone mineral density (BMD) and its associated high risk factors. Methods After a written informed consent, a detailed history was taken, baseline height and weight were recorded, biochemical and endocrine tests were done, and dual-energy x-ray absorptiometry scan were performed. Results Average age of the study population was 46.65 years and BMI 26.23 kg/m2. The prevalence of osteopenia in the study population was 38%, and of osteoporosis was 4%; the overall prevalence of low BMD was 42%. Proportion of women with low BMD increased with advancing age and menopausal status. On the endocrine evaluation, 60% cases with insufficient vitamin D, 56.67% with hyperparathyroidism, 100% with hypothyroidism and 75% with hyperthyroidism were found to have low BMD. Among chronic diseases, 83.33%women with diabetes, 50% with hypertension, 50% with liver disorder and 50% with rheumatoid arthritis were found to have low BMD. 48.65% women with sun exposure less than one hour daily had poor bone mineralization. The proportion of women with normal BMD decreased from 72.72% to 46.15%with decrease in daily physical work. In the logistic regression analysis, insufficient serum vitamin D concentrations, less physical work and inadequate sun exposure were found to be significantly associated with low BMD. Conclusion Low BMD is not a disorder confined to postmenopausal women alone. It is widely prevalent in women above 40 years of age.
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