| Objective To explore the relationship between homocysteine, vitamin D and vitamin B12 levels and BMD in postmenopausal women with osteoporosis and without osteoporosis. Methods A total of 138 women from our hospital were enrolled from August 2017 to December 2017. According to bone density, postmenopausal women were divided into two groups, osteoporosis group (OP, n=58) and non-osteoporosis group (NOP, n=80). General clinical data such as body mass index (BMI), age, and waist circumference were recorded in the two groups. BMD of lumbar spine L1-4 anteroposterior and left femur was measured. Serum levels of homocysteine, vitamin D, vitamin B12, alkaline phosphatase, calcium and phosphorus were measured. The differences of indicators in the two groups of patients and the correlation between homocysteine, vitamin D, vitamin B12 and BMD were analyzed. Results The results showed a statistically significant difference in age, BMI, waist circumference, homocysteine, vitamin D, vitamin B12, and lumbar L1-4 and left femoral neck bone density between the two groups (all P<0.05). Rho correlation and regression analyses showed that homocysteine was significantly negatively correlated with vitamin D and B12 in postmenopausal women with no osteoporosis, and significantly negatively correlated with vitamin B12 in postmenopausal women with osteoporosis. Conclusion Serum homocysteine levels were predicted by vitamin D in postmenopausal non-osteoporotic women and by vitamin B12 in postmenopausal osteoporotic women. |