| Objective: To investigate the effect of exercise intervention on the toxic effects and osteoporosis induced by doxorubicin, and to provide a theoretical reference for the development of a practical exercise prescription for the recovery of fitness in cancer patients. METHODS: In this study, 50 mice were used, all mice were fed adaptive for 1 week and bone density and bone metabolism were measured in advance during this week (bone density, bone metabolism); Grouping, control group (C group n=10), doxorubicin control group (DOX group, group D, n=10), treadmill exercise + doxorubicin group (Run+Dox group, RD group n =10), vibration training + adriamycin group (Vibration+Dox group, VD group n=10), treadmill+vibration + doxorubicin group (Run+ Vibration+Dox group, RVD group n=10) group, RD group , VD group and RVD group started exercise program. C group and D group mice were fed normally in cages; D group, RD group, VD group and RVD group began daily intraperitoneal injection on the 15th day of exercise intervention. The mice were dosed with DOX for 10 consecutive days. C mice in group C were injected with the same amount of physiological saline in the same cycle. The whole experiment period was 8 weeks, and post-test (bone density, bone metabolism, cardiac ultrasound images, and heart function) was performed after 8 weeks. Results: Ventricular posterior wall contraction (PWs), posterior wall diastolic (PWd) index, ventricular thickness in group D was significantly lower than that in group C (p<0.05), RD group, VD group thickness was significantly higher than that in group D (p<0.05) ,and significantly lower than C group (p<0.05); RVD group ventricular thickness was significantly higher than D group (p<0.05), its thickness is lower than C group, higher than RD group and VD group, but not statistically significant Significance (p>0.05). Ventricular septal contraction (IVSs) index, the ventricular thickness in group D was significantly lower than that in group C (p<0.05), and the thickness of RD group and VD group was significantly higher than that of group D (p<0.05), and was significantly lower than that of group C in posterior wall dilation ( p<0.05); Ventricular diastolic thickness (IVSs) in the ventricle; Ventricular ventricular contractions (IDs); Ventricular diastolic (IDs); ventricular wall relative thickness (RWTs) during systole; ventricular relative thickness (RWTs) during diastole For other indicators, there was no significant difference among the groups (p>0.05). The bone mineral density index had no significant difference among the groups before the test, p>0.05. The post-test results of group D, RD, and VD were significantly lower than those before the test, p<0.05. There was no significant difference between post-test and pretest in group C and RVD, p>0.05. The post-test results in group D were significantly lower than those in group C (p<0.05 RD group). The post-test results in group VD were significantly higher than group D (p<0.05), and significantly lower than group C (p<0.05); the post-test results of RVD group were significant. Greater than D group. 2) Ca2, ALP, BGP and TRACP5b indicators did not show significant differences in each group, p>0.05. The post-test results of group D, RD group, VD group, and RVD group were significantly higher than those before the test, p<0.05. There was no significant difference between posttest and pretest in group C, p>0.05. The post-test results of group D were significantly lower than that of group C (p<0.05). The post-test results of RD group and VD group were significantly lower than that of group D (p<0.05), and significantly higher than that of group C (p<0.05). Post-test results of RVD group Significantly lower than the D group, RD group, VD group (p <0.05), significantly higher than the C group (p <0.05). Conclusion: The use of doxorubicin may lead to thinning of heart wall and decrease of blood flow in the heart of mice, and treadmill intervention and vibration intervention will inhibit the thickness of left ventricular wall thickness and heart induced by doxorubicin in a certain extent. Blood flow was reduced, and treadmill combined with vibration intervention significantly inhibited adriamycin-induced left ventricular wall thickness and cardiac blood flow in mice. The use of doxorubicin may lead to decreased bone mineral density and increased bone resorption in mice. Low-intensity running exercises combined with low-intensity vibration training have high operability for cancer patients treated with doxorubicin, and they are able to Doxorubicin-induced osteoporosis has a good preventive and therapeutic effect. |