| Objective To analyze the clinical curative effect of zoledronic acid combined with alfa-calcidol and calcium tablets in the treatment of osteoporosis. Methods From April 2015 to April 2018, 102 patients with osteoporosis in our hospital were recruited, and randomized into the control group (51 cases, simple calcium-tablet therapy) and test group (51 cases, zoledronic acid + alfa-calcidol + calcium tablets) using random digital table method. Bone mineral density, clinical efficacy, VAS score and quality of life were compared between the two groups. Results The BMD of the experimental group at proximal femur, greater trochanter, femoral neck and L1-L4 was all significantly higher than that of the control group, P<0.05. The total clinical efficiency of the experimental group was significantly higher than that of the control group, P<0.05 (with statistical difference). VAS score of the experimental group was significantly lower than that of the control group, P<0.05 (with statistical difference). The quality of life score of the experimental group was significantly higher than that of the control group, P<0.05 (with statistical difference). Conclusion Combined with alfa-calcidol and calcium tablets, zoledronic acid could effectively improve bone density, alleviate pain symptoms and improve quality of life in patients with osteoporosis. |