Objective To explore the risk factors of osteoporosis in elder type 2 diabetic patients (T2DM). Methods A total of 273 cases of elder T2DM patients in the First Hospital of Wuhan from May 2016 to April 2018 were collected. Patients were divided to osteoporosis group (OP group, 125 cases) and non-OP group (148cases) according to the BMD values. Sex, age, course of disease, BMI, levels of blood calcium (Ca), blood phosphorus (P), alkaline phosphatase (ALP), fasting blood-glucose (FBG), fasting insulin (Fins), hemoglobin AIC (HbAlc), serum creatinine (scr), triglyceride (Tg), total cholesterol (Tc), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and insulin-like growth factor-1 (IGF-1) were recorded. The homeostasis model assessment insulin resistance (HOMA-IR) was calculated. The clinical data were compared between the two groups. Results The course of disease, BMI, HbA1c, scr,and IGF-1 were significantly different between patients in OP group and non-OP group (P<0.05). However, age, sex, Ca, P, ALP, HOMA-IR, Tg, Tc, HDL-C, and LDL-C were not different between the two groups (P> 0.05). Logistic regression analysis revealed that longer course of disease, lower BMI, and lower IGF-1 were correlated with osteoporosis. Conclusion The course of disease, BMI, and level of blood IGF-1 are the risk factors of osteoporosis in elder type 2 diabetes patients. |